- PO (Adults): Therapy-nave: 400 mg once daily or 300 mg once daily with ritonavir 100 mg once daily (must be used with ritonavir in pregnancy); should be used at a dose of 300 mg once daily with ritonavir 100 mg once daily if used concomitantly with tenofovir, H2 receptor antagonist, or proton pump inhibitor; should be used at a dose of 400 mg once daily with ritonavir 100 mg once daily if used concomitantly with efavirenz. Therapy-experienced: 300 mg once daily with ritonavir 100 mg once daily; should be used at dose of 400 mg once daily with ritonavir 100 mg once daily if used with tenofovir and a H2 receptor antagonist; in pregnant patients in 2nd or 3rd trimester, should be used at a dose of 400 mg once daily with ritonavir 100 mg once daily if used with tenofovir or a H2 receptor antagonist.
- PO, (Capsules) (Children
6 yr): Therapy–nave or therapy–experienced (15–34.9 kg): 200 mg once daily with ritonavir 100 mg once daily; Therapy–nave or therapy–experienced (35 kg): 300 mg once daily with ritonavir 100 mg once daily; Therapy–nave, 13 yr, 40 kg and unable to tolerate ritonavir: 400 mg once daily. - PO, (Oral Powder) (Children 3 mo and 5 kg): Therapy–nave or therapy–experienced (5–14.9 kg): 200 mg once daily with ritonavir 80 mg once daily; Therapy–nave or therapy–experienced (15–24.9 kg): 250 mg once daily with ritonavir 80 mg once daily.
Renal Impairment
- PO (Adults): Therapy-naive and hemodialysis: 300 mg once daily with ritonavir 100 mg once daily; Therapy-experienced and hemodialysis: contraindicated.
Hepatic Impairment
- PO (Adults): Moderate hepatic impairment: 300 mg once daily (do not use with ritonavir).