URE-i-deen trye-AS-e-tate
Therapeutic Classification: antidotes
Pharmacologic Classification: pyrimidine analogs
Absorption: Well absorbed following oral administration.
Distribution: Crosses the blood-brain barrier.
Metabolism/Excretion: Undergoes catabolic metabolism in tissues; primarily excreted in urine.
Half-Life: 2–2.5 hr.
Overdose
- PO: Administer as soon as possible after overdose or signs of early—onset of toxicity within 96 hrs following end of fluorouracil or capecitabine administration. Administer full course (20 doses).
- Mix granules with 3–4 ounces of soft food (applesauce, pudding, yogurt) and ingest within 30 min of mixing. Do not chew granules. Drink at least 4 ounces of water.
- If vomiting occurs within 2 hrs of dose, administer another dose as soon as possible after vomiting. Administer next dose at scheduled time.
- May be administered via NG tube or G-tube. Prepare 4 fluid ounces (100 mL) of a food starch-based thickening product in water and stir briskly until thickener has dissolved. Crush contents of 10 g packet to fine powder. Add crushed granules to reconstituted food starch-based thickening product. For pediatric patients receiving <10 g, prepare mixture at a ratio of not >1 g/10 mL reconstituted food starch-based thickening product and mix thoroughly. Flush tube with water after administration.
- PO: Adults: administer 1 packet every 6 hrs for 20 doses without regard to meals. Do not exceed 10 g dose.
- Pediatric: measure dose using a scale accurate to at least 0.1 g, or a graduated teaspoon accurate to 1/4 teaspoon. Discard unused portion of granules; do not use granules left in open package for subsequent doses.
Hereditary orotic aciduria
- PO: Administer 60 mg/kg once daily. Xuriden 2 g packet = 3/4 teaspoon. Measure dose using either a scale accurate to at least 0.1 gram, or a graduated teaspoon, accurate to fraction of dose. See manufacturer's guidelines for specific weight and dose in teaspoon amounts. Once dose removed from packet, discard packet; do not use for next dose. May increase dose to 120 mg/kg if levels of urine orotic acid remain > normal or ↑ above usual or expected range for patient, worsening of lab values affected by heretic orotic aciduria (RBC and WBC indices), or worsening or other signs and symptoms of the disease. Store packets at room temperature.
- Adults: Mix granules with 3–4 ounces of soft food (applesauce, pudding, yogurt) and ingest within 30 min of mixing. Do not chew granules. Follow by drinking at least 4 ounces of water.
- Pediatric: Mix with milk or infant formula instead of soft food described above for patients receiving 2 g (3/4 teaspoon) dose. Pour 5 mL of milk or infant formula into 30 mL medicine cup. Using oral syringe, draw up 5 mL of mixture. Hold tip upright and pull down plunger to 10 mL to add air; cap syringe. Point syringe tip down and remove plunger to add measured granules to syringe; cap syringe. Gently swirl to mix. With syringe tip up, remove cap, and expel air. Place syringe tip at back of mouth between cheek and gum; gently push plunger to administer all mixture. Refill syringe with another 5 mL milk/infant formula and swirl to remove remaining granules from syringe barrel. Administer as above. Follow with bottle of milk or infant formula if desired.