econazole

Therapeutic Classification: antifungals (topical)

REMS

Cream

Treatment of a variety of cutaneous fungal infections, including cutaneous candidiasis, tinea pedis (athlete’s foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor.

Foam

Treatment of interdigital tinea pedis

Affects the permeability of the fungal cell wall, allowing leakage of cellular contents.

Therapeutic effects:

Decrease in symptoms of fungal infection.

Absorption: Absorption through intact skin is minimal.

Distribution: Distribution after topical administration is primarily local.

Metabolism/Excretion: Metabolism in the liver and <1% excreted in the urine and feces.

Half-Life: Not applicable.

ROUTE	ONSET	PEAK	DURATION
Top	unknown	unknown	unknown

Contraindicated in:

Hypersensitivity to active ingredients, additives, preservatives, or bases.

Use Cautiously in:

Nail and scalp infections (may require additional systemic therapy);
OB: Safety not established.

Local: burning, itching, local hypersensitivity reactions, redness, stinging

Drug-drug:

May ↑ levels of and risk of bleeding from warfarin.

(Adults and Children ): Apply once daily in patients with tinea pedis (for 1 mo), tinea cruris (for 2 wk), tinea corporis (for 2 wk), and tinea versicolor (for 2 wk). Apply twice daily in patients with cutaneous candidiasis (for 2 wk).

(Generic available)

Cream: 1%
Foam: 1%

Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.

Lab Test Considerations:

Monitor INR and/or prothrombin time in patients taking warfarin and applying econazole to large body surface areas, in genital area, or under occlusion.

Consult health care professional for proper cleansing technique before applying medication.
Apply small amount to cover affected area completely. Avoid the use of occlusive wrappings or dressings unless directed by health care professional.

Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes.
Caution patient that some products may stain fabric, skin, or hair. Check label information. Fabrics stained from cream can usually be cleaned by handwashing with soap and warm water.
Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
Advise patient to report increased skin irritation or lack of response to therapy to health care professional.
Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Advise patient that early relief of symptoms may be seen in 2–3 days. For Candida, tinea cruris, tinea corporis, and tinea versicolor, 2 wk are needed, and for tinea pedis, therapeutic response may take 4 wk. Recurrent fungal infections may be a sign of systemic illness.

Decrease in skin irritation.
Resolution of infection.

NDC Code

0168- E. Fougera and Co. a division of Fougera Pharmaceuticals Inc.
- 0168-0312- Econazole Nitrate
  - 0168-0312-15- 15 g in 1 TUBE (0168-0312-15)

0168- E. Fougera and Co. a division of Fougera Pharmaceuticals Inc.
- 0168-0312- Econazole Nitrate
  - 0168-0312-30- 30 g in 1 TUBE (0168-0312-30)

0168- E. Fougera and Co. a division of Fougera Pharmaceuticals Inc.
- 0168-0312- Econazole Nitrate
  - 0168-0312-85- 85 g in 1 TUBE (0168-0312-85)

0378- Mylan Pharmaceuticals Inc.
- 0378-7625- Econazole Nitrate
  - 0378-7625-15- 1 TUBE in 1 CARTON (0378-7625-15) > 15 g in 1 TUBE

0378- Mylan Pharmaceuticals Inc.
- 0378-7625- Econazole Nitrate
  - 0378-7625-49- 1 TUBE in 1 CARTON (0378-7625-49) > 30 g in 1 TUBE

0378- Mylan Pharmaceuticals Inc.
- 0378-7625- Econazole Nitrate
  - 0378-7625-85- 1 TUBE in 1 CARTON (0378-7625-85) > 85 g in 1 TUBE

23710- Exeltis USA Dermatology, LLC
- 23710-100- ECOZA
  - 23710-100-10- 1 CAN in 1 CARTON (23710-100-10) > 10 g in 1 CAN

23710- Exeltis USA Dermatology, LLC
- 23710-100- ECOZA
  - 23710-100-70- 1 CAN in 1 CARTON (23710-100-70) > 70 g in 1 CAN

23710- Exeltis USA Dermatology, LLC
- 23710-100- ECOZA
  - 23710-100-75- 1 CAN in 1 CARTON (23710-100-75) > 70 g in 1 CAN

33261- Aidarex Pharmaceuticals LLC
- 33261-956- Econazole Nitrate
  - 33261-956-01- 1 TUBE in 1 CARTON (33261-956-01) > 15 g in 1 TUBE

45802- Perrigo New York Inc
- 45802-466- Econazole Nitrate
  - 45802-466-11- 1 TUBE in 1 CARTON (45802-466-11) > 30 g in 1 TUBE

45802- Perrigo New York Inc
- 45802-466- Econazole Nitrate
  - 45802-466-35- 1 TUBE in 1 CARTON (45802-466-35) > 15 g in 1 TUBE

45802- Perrigo New York Inc
- 45802-466- Econazole Nitrate
  - 45802-466-53- 1 TUBE in 1 CARTON (45802-466-53) > 85 g in 1 TUBE

51672- Taro Pharmaceuticals U.S.A., Inc.
- 51672-1303- Econazole Nitrate
  - 51672-1303-1- 1 TUBE in 1 CARTON (51672-1303-1) > 15 g in 1 TUBE

51672- Taro Pharmaceuticals U.S.A., Inc.
- 51672-1303- Econazole Nitrate
  - 51672-1303-2- 1 TUBE in 1 CARTON (51672-1303-2) > 30 g in 1 TUBE

51672- Taro Pharmaceuticals U.S.A., Inc.
- 51672-1303- Econazole Nitrate
  - 51672-1303-8- 1 TUBE in 1 CARTON (51672-1303-8) > 85 g in 1 TUBE

52565- Teligent Pharma, Inc.
- 52565-022- Econazole Nitrate
  - 52565-022-15- 1 TUBE in 1 CARTON (52565-022-15) > 15 g in 1 TUBE

52565- Teligent Pharma, Inc.
- 52565-022- Econazole Nitrate
  - 52565-022-30- 1 TUBE in 1 CARTON (52565-022-30) > 30 g in 1 TUBE

52565- Teligent Pharma, Inc.
- 52565-022- Econazole Nitrate
  - 52565-022-85- 1 TUBE in 1 CARTON (52565-022-85) > 85 g in 1 TUBE

68788- Preferred Pharmaceuticals Inc.
- 68788-7346- Econazole Nitrate
  - 68788-7346-1- 1 TUBE in 1 CARTON (68788-7346-1) > 15 g in 1 TUBE

68788- Preferred Pharmaceuticals Inc.
- 68788-7346- Econazole Nitrate
  - 68788-7346-3- 1 TUBE in 1 CARTON (68788-7346-3) > 30 g in 1 TUBE

68788- Preferred Pharmaceuticals Inc.
- 68788-7406- Econazole Nitrate
  - 68788-7406-1- 15 g in 1 TUBE (68788-7406-1)

68788- Preferred Pharmaceuticals Inc.
- 68788-7406- Econazole Nitrate
  - 68788-7406-3- 1 TUBE in 1 CARTON (68788-7406-3) > 30 g in 1 TUBE

70512- SOLA Pharmaceuticals
- 70512-029- Econazole Nitrate
  - 70512-029-30- 1 TUBE in 1 CARTON (70512-029-30) > 30 g in 1 TUBE

70512- SOLA Pharmaceuticals
- 70512-029- Econazole Nitrate
  - 70512-029-85- 1 TUBE in 1 CARTON (70512-029-85) > 85 g in 1 TUBE

72657- Glenmark Therapeutics Inc.,USA
- 72657-200- ECOZA
  - 72657-200-70- 1 CAN in 1 CARTON (72657-200-70) > 70 g in 1 CAN

72657- Glenmark Therapeutics Inc.,USA
- 72657-200- ECOZA
  - 72657-200-99- 1 CAN in 1 CARTON (72657-200-99) > 10 g in 1 CAN

section name header

Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Code ⬆