section name header

Pronunciation

kwet-EYE-a-peen

Classifications

Therapeutic Classification: antipsychotics, mood stabilizers

Indications

BEERS REMS


Action

  • Probably acts by serving as an antagonist of dopamine and serotonin.
  • Also antagonizes histamine H1 receptors and alpha1-adrenergic receptors.
Therapeutic effects:
  • Decreased manifestations of psychoses, depression, or acute mania.

Pharmacokinetics

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed.

Metabolism/Excretion: Extensively metabolized by the liver via the CYP3A4 isoenyzme to norquetiapine (active metabolite with anticholinergic properties); <1% excreted unchanged in the urine.

Half-Life: 6 hr.

Time/Action Profile

(antipsychotic effects)

ROUTEONSETPEAKDURATION
POunknownunknown8–12 hr
PO-XRunknownunknownunknown



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: BP (children), palpitations, peripheral edema, postural hypotension

Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), STEVENS-JOHNSON SYNDROME (SJS), sweating

EENT: ear pain, pharyngitis, rhinitis

Endo: hyperglycemia, hyperprolactinemia, hypothyroidism

GI: anorexia, constipation, dry mouth, dyspepsia, GI OBSTRUCTION, PANCREATITIS

GU: fertility (females)

Hemat: hemoglobin, AGRANULOCYTOSIS, leukopenia, neutropenia

Metab: weight gain, hyperlipidemia, hypertriglyceridemia

MS: rhabdomyolysis

Neuro: dizziness, cognitive impairment, extrapyramidal symptoms, NEUROLEPTIC MALIGNANT SYNDROME, sedation, SEIZURES, tardive dyskinesia

Resp: cough, dyspnea

Misc: flu-like syndrome

Interactions

Drug-drug:

Route/Dosage

Schizophrenia

Acute Manic Episodes Associated With Bipolar I Disorder

Acute Depressive Episodes Associated With Bipolar Disorder

Maintenance Treatment of Bipolar I Disorder

Depression

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

SEROquel, SEROquel XR

Pill Image

seroquel_195-8483.jpg

Code

NDC Code