section name header

Pronunciation

klor-fen-IR-a-meen

Classifications

Therapeutic Classification: allergy, cold and cough remedies, antihistamines

Indications

BEERS REMS


Action

  • Antagonizes the effects of histamine at H1-receptor sites; does not bind to or inactivate histamine.
Therapeutic effects:
  • Decreased symptoms of histamine excess (sneezing, rhinorrhea, nasal and ocular pruritus, ocular tearing, and redness).

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Widely distributed. Minimal amounts excreted in breast milk. Crosses the blood-brain barrier.

Metabolism/Excretion: Extensively metabolized by the liver.

Half-Life: 12–15 hr.

Time/Action Profile

(antihistaminic effects)

ROUTEONSETPEAKDURATION
PO15–30 min6 hr4–12 hr
PO–ERunknownunknown8–24 hr



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypertension, arrhythmias, hypotension, palpitations

EENT: blurred vision

GI: dry mouth, GI obstruction, constipation

GU: retention, urinary hesitancy

Neuro: drowsiness, dizziness, excitation (in children)

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Aller-Chlor, Chlor-Trimeton, Chlor-Trimeton Allergy, Ed Chlorped Jr

Code

NDC Code