- PO (Adults): 250–500 mg q 6 hr or 500 mg–1 g q 12 hr. Chronic treatment of acne: 500 mg–2 g/day for 3 wk, then ↓ to 125 mg–1 g/day.
- PO (Children
8 yr): 6.25–12.5 mg/kg q 6 hr or 12.5–25 mg/kg q 12 hr.
Spectrum:
Absorption: 60–80% absorbed after oral administration.
Distribution: Widely distributed, some CSF and good bone penetration; crosses the placenta and enters breast milk.
Metabolism/Excretion: Excreted mostly unchanged by the kidneys.
Half-life: 6–12 hr.
Contraindicated in:
Use Cautiously in:
Derm: photosensitivity, rashes.
GI: diarrhea, nausea, vomiting, esophagitis, hepatotoxicity, pancreatitis.
Hemat: blood dyscrasias.
Neuro: dizziness, intracranial hypertension.
Misc: hypersensitivity reactions, superinfection.
Drug-Drug:
Drug-Food:
8 yr): 6.25–12.5 mg/kg q 6 hr or 12.5–25 mg/kg q 12 hr.(Generic available)
NDC Code*