me-TOE-proe-lole
Therapeutic Classification: antianginals, antihypertensives
Pharmacologic Classification: beta blockers
High Alert
Absorption: Well absorbed after oral administration.
Distribution: Crosses the blood-brain barrier, crosses the placenta; small amounts enter breast milk.
Half-Life: 3–7 hr.
(cardiovascular effects)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO‡ | 15 min | unknown | 6–12 hr |
| PO–ER | unknown | 6–12 hr | 24 hr |
| IV | immediate | 20 min | 5–8 hr |
‡Maximal effects on BP (chronic therapy) may not occur for 1 wk. Hypotensive effects may persist for up to 4 wk after discontinuation.
Contraindicated in:
Use Cautiously in:
CV: BRADYCARDIA, heart block, HF, hypotension, peripheral vasoconstriction
Derm: rash
EENT: blurred vision, stuffy nose
Endo: hyperglycemia, hypoglycemia
GI: ↑liver enzymes, constipation, diarrhea, drug-induced hepatitis, dry mouth, flatulence, gastric pain, heartburn, nausea, vomiting
GU: erectile dysfunction, ↓libido, urinary frequency
MS: arthralgia, back pain, joint pain
Neuro: fatigue, weakness, anxiety, depression, dizziness, drowsiness, insomnia, memory loss, mental status changes, nervousness, nightmares
Resp: bronchospasm, PULMONARY EDEMA, wheezing
Misc: drug-induced lupus syndrome
Drug-drug:
When switching from immediate-release to extended-release product, the same total daily dose can be used
Lab Test Considerations:
IV vasoactive medications are inherently dangerous. Before administering intravenously, have second practitioner independently check original order and dose calculations.
Do not confuse Toprol-XL with Topamax. Do not confuse Lopressor with Lyrica. Do not confuse metoprolol tartrate with metoprolol succinate.
IV Administration:
NDC Code
