section name header

Pronunciation

or-FENN-a-dreen

Classifications

Therapeutic Classification: skeletal muscle relaxants (centrally acting)

Pharmacologic Classification: diphenhydramine analogues

Indications

BEERS REMS


Action

  • Skeletal muscle relaxation, probably due to CNS depression.
Therapeutic effects:
  • Skeletal muscle relaxation, with decreased discomfort.

Pharmacokinetics

Absorption: Readily absorbed after oral and IM administration; IV administration results in complete bioavailability.

Distribution: Unknown.

Metabolism/Excretion: Mostly metabolized by the liver.

Half-Life: 14 hr.

Time/Action Profile

(skeletal muscle effects)

ROUTEONSETPEAKDURATION
PO-ERwithin 1 hr6–8 hr12 hr
IM5 min30 min12 hr
IVimmediateunknown12 hr

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: orthostatic hypotension, tachycardia

EENT: blurred vision, dry eyes

GI: constipation, dry mouth

GU: urinary retention

Neuro: CNS excitation, confusion, dizziness, drowsiness

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

IV Administration:

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Norflex

Code

NDC Code