sef-try-AX-one
Therapeutic Classification: anti-infectives
Pharmacologic Classification: third generation cephalosporins
REMS
Spectrum:
Absorption: Well absorbed following IM administration; IV administration results in complete bioavailability.
Distribution: Widely distributed. CSF penetration better than with first- and second-generation agents. Crosses the placenta; enters breast milk in low concentrations.
Protein Binding: ≥90%.
Half-Life: 6–9 hr.
Contraindicated in:
Use Cautiously in:
Derm: rash, urticaria
GI: CLOSTRIDIODES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), cholelithiasis, diarrhea, gallbladder sludging, pancreatitis
GU: acute renal failure, urolithiasis
Hemat: bleeding, eosinophilia, hemolytic anemia, leukopenia, thrombocytosis
Local: pain at IM site, phlebitis at IV site
Neuro: encephalopathy, SEIZURES (HIGH DOSES)
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS) , superinfection
Drug-drug:
Lab Test Considerations:
IV Administration:
NDC Code