section name header

Pronunciation

klor-PROE-ma-zeen

Classifications

Therapeutic Classification: antiemetics, antipsychotics

Pharmacologic Classification: phenothiazines

Indications

BEERS REMS


Action

  • Alters the effects of dopamine in the CNS.
  • Has significant anticholinergic/alpha-adrenergic blocking activity.
Therapeutic effects:
  • Diminished signs/symptoms of psychosis and bipolar disorder.
  • Relief of nausea/vomiting/intractable hiccups.
  • Decreased symptoms of porphyria.

Pharmacokinetics

Absorption: Variable absorption from tablets. Well absorbed following IM administration.

Distribution: Widely distributed; high CNS concentrations.

Protein Binding: 90%.

Metabolism/Excretion: Highly metabolized by the liver and GI mucosa. Some metabolites are active.

Half-Life: 30 hr.

Time/Action Profile

(antipsychotic activity, antiemetic activity, sedation)

ROUTEONSETPEAKDURATION
PO30–60 minunknown4–6 hr
IMunknownunknown4–8 hr
IVrapidunknownunknown



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypotension ( with IM, IV), tachycardia

Derm: photosensitivity, pigment changes, rash

EENT: blurred vision, dry eyes, lens opacities

Endo: amenorrhea, galactorrhea

GI: constipation, dry mouth, anorexia, hepatitis, ileus, priapism

GU: urinary retention

Hemat: AGRANULOCYTOSIS, leukopenia

Metab: hyperthermia

Neuro: sedation, extrapyramidal reactions, NEUROLEPTIC MALIGNANT SYNDROME, tardive dyskinesia

Misc: allergic reactions

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

IV Administration:

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Thorazine

Code

NDC Code