thee-OFF-i-lin
Absorption: Well absorbed from PO dosage forms; absorption from extended-release dosage forms is slow but complete.
Distribution: Widely distributed; crosses the placenta and into breast milk; does not distribute into adipose tissue.
Half-Life: Theophylline—Premature infants: 20–30 hr; Term infants: 11–25 hr; Children 1–4 yr: 3.4 hr; Children 6–17 yr: 3.7 hr; Adults: 9–10 hr (↑ in patients >60 yr, patients with HF or liver disease; ↓ in cigarette smokers ).
(bronchodilation)
| ROUTE | ONSET‡ | PEAK | DURATION |
|---|---|---|---|
| PO | rapid | 1–2 hr | 6 hr |
| PO-ER | delayed | 4–8 hr | 8–24 hr |
| IV | rapid | end of infusion | 6–8 hr |
‡Provided that a loading dose has been given and steady-state blood levels exist.
Contraindicated in:
Use Cautiously in:
CV: ARRHYTHMIAS, tachycardia, angina, palpitations
GI: nausea, vomiting, anorexia
Neuro: tremor, SEIZURES, anxiety, headache, insomnia, irritability
Drug-drug:
Drug-Natural Products:
Generic
100 mg
23.86
100
200 mg
36.50
100
300 mg
51.11
100
450 mg
68.27
100
100 mg; 200 mg; 300 mg; 450 mgGeneric
400 mg
135.76
100
600 mg
196.17
100
400 mg; 600 mg100 mg
149.16
100
200 mg
221.69
100
300 mg
272.46
100
400 mg
383.38
100
100 mg; 200 mg; 300 mg; 400 mgGeneric
83.04
473 mL
80 mg/15 mLLab Test Considerations:
Toxicity and Overdose:
Y-Site Incompatibility:
Admixing is not recommended because of dose titration and incompatibilities.
NDC Code