Therapeutic Classification: antirheumatics
Pharmacologic Classification: dmards, monoclonal antibodies
Absorption: 64% absorbed after SUBQ administration.
Distribution: Synovial fluid concentrations are 31–96% of serum.
Metabolism/Excretion: Unknown.
Half-Life: 14 days (range 10–20 days).
Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis
- SC (Adults ): 40 mg every other wk. Methotrexate, non-biologic DMARDs, corticosteroids, and/or analgesics may be continued during therapy. Patients not receiving concurrent methotrexate may receive additional benefit by ↑ dose to 40 mg once weekly or 80 mg every other wk.
Crohn's Disease
- SC (Adults ): 160 mg initially on Day 1 (given in one day or over two consecutive days), followed by 80 mg 2 wk later on Day 15. Two wk later (Day 29), begin maintenance dose of 40 mg every other wk. Aminosalicylates, corticosteroids, and/or immunomodulatory agents (e.g. azathioprine, 6–mercaptopurine, methotrexate) may be continued during therapy.
- SC (Children ≥6 yr and ≥40 kg): Abrilada, Amjevita, Hadlima, Hulio, Humira, Idacio, and Hyrimoz only: 160 mg initially on Day 1 (given in one day or over two consecutive days), followed by 80 mg 2 wk later on Day 15. Two wk later (Day 29), begin maintenance dose of 40 mg every other wk. Aminosalicylates, corticosteroids, and/or immunomodulatory agents (e.g. azathioprine, 6–mercaptopurine, methotrexate) may be continued during therapy.
- SC (Children ≥6 yr and 17–<40 kg): Abrilada, Amjevita, Hadlima, Hulio, and Humira only: 80 mg initially on Day 1, followed by 40 mg 2 wk later on Day 15. Two wk later (Day 29), begin maintenance dose of 20 mg every other wk. Aminosalicylates, corticosteroids, and/or immunomodulatory agents (e.g. azathioprine, 6–mercaptopurine, methotrexate) may be continued during therapy.
Ulcerative Colitis
- SC (Adults ): 160 mg initially on Day 1 (given in one day or over two consecutive days), followed by 80 mg 2 wk later on Day 15. Two wk later (Day 29), begin maintenance dose of 40 mg every other wk. Aminosalicylates, corticosteroids, and/or immunomodulatory agents (e.g. azathioprine, 6–mercaptopurine, methotrexate) may be continued during therapy. Should be continued only if patients have evidence of clinical remission by wk 8 of therapy.
- SC (Children ≥5 yr and ≥40 kg): Humira only: 160 mg initially on Day 1 (given in one day or over two consecutive days), followed by 80 mg 1 wk later on Day 8, and then followed by 80 mg 1 wk later on Day 15. Two wk later (Day 29), begin maintenance dose of either 80 mg every other wk or 40 mg every wk. Aminosalicylates, corticosteroids, and/or immunomodulatory agents (e.g. azathioprine, 6–mercaptopurine, methotrexate) may be continued during therapy.
- SC (Children ≥5 yr and 20–<40 kg): Humira only: 80 mg initially on Day 1, followed by 40 mg 1 wk later on Day 8, and then followed by 40 mg 1 wk later on Day 15. Two wk later (Day 29), begin maintenance dose of either 40 mg every other wk or 20 mg every wk. Aminosalicylates, corticosteroids, and/or immunomodulatory agents (e.g. azathioprine, 6–mercaptopurine, methotrexate) may be continued during therapy.
Juvenile Idiopathic Arthritis
- SC (Children 2–17 yr (Abrilada, Amjevita, Hadlima, Hulio, Humira, Idacio, and Hyrimoz); 4–17 yr (Cyltezo): 10–<15 kg (Abrilada, Hadlima, Humira, and Hyrimoz only): 10 mg every other wk; 15–<30 kg (Abrilada, Amjeveta, Hadlima, Hulio, and Humira only): 20 mg every other wk; ≥30 kg: 40 mg every other wk.
Plaque Psoriasis
- SC (Adults ): 80 mg initially, then in 1 wk, begin regimen of 40 mg every other wk.
Uveitis
- SC (Adults ): Abrilada, Amjevita, Cyltezo, Hadlima, Hulio, or Humira only: 80 mg initially, then in 1 wk, begin regimen of 40 mg every other wk.
- SC (Children ≥2 yr and ≥30 kg): Humira only: 40 mg every other wk.
- SC (Children ≥2 yr and 15–<30 kg): Humira only: 20 mg every other wk.
- SC (Children ≥2 yr and 10–<15 kg): Humira only: 10 mg every other wk.
Hidradenitis Suppurativa
- SC (Adults ): Abrilada, Amjevita, Cyltezo, Hadlima, Humira, or Yusimry: 160 mg initially (given in one day or over two consecutive days), followed by 80 mg 2 wk later on Day 15. Two wk later (Day 29), begin maintenance dose of 40 mg every wk or 80 mg every other wk.
- SC (Children ≥12 yr and ≥60 kg): Humira only: 160 mg initially (given in one day or over two consecutive days), followed by 80 mg 2 wk later on Day 15. Two wk later (Day 29), begin maintenance dose of 40 mg every wk or 80 mg every other wk.
- SC (Children ≥12 yr and 30–59 kg): Humira only: 80 mg initially on Day 1, followed by 40 mg 1 wk later on Day 8. Two wk later (Day 22), begin maintenance dose of 40 mg every other wk.
