section name header

Pronunciation ⬇

klor-THAL-i-doan

Classifications ⬆ ⬇

Therapeutic Classification: antihypertensives, diuretics

Pharmacologic Classification: thiazide diuretics

Indications ⬆ ⬇

BEERS REMS

Action ⬆ ⬇

  • Increases excretion of sodium and water by inhibiting sodium reabsorption in the distal tubule.
  • Promotes excretion of chloride, potassium, magnesium, and bicarbonate.
  • May produce arteriolar dilation.
Therapeutic effects:
  • Lowering of BP in hypertensive patients and diuresis with mobilization of edema.

Pharmacokinetics ⬆ ⬇

Absorption: Rapidly absorbed after administration.

Distribution: Distributed into extracellular space; crosses the placenta and enters breast milk.

Metabolism/Excretion: Excreted mainly unchanged by the kidneys.

Half-Life: 35–50 hr.

Time/Action Profile ⬆ ⬇

(diuretic effect)

ROUTEONSETPEAKDURATION
PO2 hr2 hr48–72 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension

Derm: photosensitivity, rash

Endo: hyperglycemia

F and E: hypokalemia, dehydration, hypercalcemia, hypochloremic alkalosis, hypomagnesemia, hyponatremia, hypophosphatemia, hypovolemia

GI: anorexia, cramping, hepatitis, nausea, PANCREATITIS, vomiting

Hemat: blood dyscrasias

Metab: hypercholesterolemia, hyperuricemia

MS: muscle cramps

Neuro: drowsiness, dizziness, lethargy, weakness

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Hypertension

Edema

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Thalitone

Code ⬆

NDC Code