section name header

Pronunciation ⬇

isosorbide dinitrate: eye-soe-SOR-bide dye-NYE-trate

isosorbide mononitrate: eye-soe-SOR-bide mo-noe-NYE-trate

Classifications ⬆ ⬇

Therapeutic Classification: antianginals

Pharmacologic Classification: nitrates

Indications ⬆ ⬇

REMS

Unlabeled Use:

Action ⬆ ⬇

Therapeutic Effects:

Pharmacokinetics ⬆ ⬇

Absorption: Isosorbide dinitrate undergoes extensive first-pass metabolism by the liver, resulting in 25% bioavailability; isosorbide mononitrate has 100% bioavailability (does not undergo first-pass metabolism).

Distribution: Unknown.

Metabolism/Excretion: Isosorbide dinitrate is metabolized by the liver to 2 active metabolites (5-mononitrate and 2-mononitrate). Isosorbide mononitrate is primarily metabolized by the liver to inactive metabolites; primarily excreted in urine as metabolites.

Half-life: Isosorbide dinitrate: 1 hr; isosorbide mononitrate: 5 hr.

Time/Action Profile ⬆ ⬇

(cardiovascular effects)

ROUTEONSETPEAKDURATION
ISDN-PO45–60 minunknown4 hr
ISMN-PO30–60 minunknown7 hr
ISMN-ERunknownunknown12 hr

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension, tachycardia, paradoxic bradycardia, syncope.

Derm: flushing.

GI: nausea, vomiting.

Neuro: dizziness, headache.

Misc: tolerance.

Interactions ⬆ ⬇

Drug-Drug:

Route/Dosage ⬆ ⬇

Isosorbide Dinitrate

Isosorbide Mononitrate

Availability ⬆ ⬇

Isosorbide Dinitrate

(generic available)

Isosorbide Mononitrate

(generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Isosorbide Dinitrate

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

isosorbide dinitrate: Dilatrate-SR

, Isordil

isosorbide mononitrate: Imdur

, Ismo, Monoket

Canadian Brand Names ⬆ ⬇

isosorbide mononitrate: Imdur

Pill Image

isosorbidemononitrate_195_8963.jpg

Code ⬆

NDC Code*