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Pronunciation ⬇

GLI-ser-in

Classifications ⬆ ⬇

Therapeutic Classification: antiglaucoma agents, laxatives

Pharmacologic Classification: osmotics

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Draws water into the lumen of the colon.
  • Osmotically draws water from extravascular spaces, including the eye, into intravascular compartment.
Therapeutic effects:
  • Relief of constipation.
  • Reduction of corneal edema.

Pharmacokinetics ⬆ ⬇

Absorption: Not significantly absorbed from colonic mucosa.

Distribution: Remains in the intravascular space.

Metabolism/Excretion: 80% metabolized by the liver, 10–20% metabolized by the kidneys.

Half-Life: 30–45 min.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
Rect (laxative effect)unknown15–30 minunknown
Ophth (reduced corneal swelling)unknownunknown3–4 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

F and E: dehydration

GI: diarrhea, nausea, cramping, vomiting

Neuro: headache, confusion

Misc: thirst

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Laxative

Reduction of Corneal Edema

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Fleet Babylax, Sani-Supp

Code ⬆

NDC Code