section name header

Pronunciation ⬇

mo-DAF-i-nil

Classifications ⬆ ⬇

Therapeutic Classification: central nervous system stimulants

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Produces CNS stimulation.
Therapeutic effects:
  • Decreased daytime drowsiness in patients with narcolepsy and obstructive sleep apnea.
  • Decreased drowsiness during work in patients with shift work sleep disorder.

Pharmacokinetics ⬆ ⬇

Absorption: Rapidly absorbed; bioavailability unknown.

Distribution: Well distributed to tissues.

Metabolism/Excretion: Highly (90%) metabolized by the liver; <10% eliminated unchanged in the urine.

Half-Life: 15 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTEONSETPEAKDURATION
POrapid2–4 hr24 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: arrhythmias, chest pain, hypertension, hypotension, syncope

Derm: dry skin, rash, STEVENS-JOHNSON SYNDROME (SJS)

EENT: rhinitis, abnormal vision, amblyopia, epistaxis, pharyngitis

Endo: hyperglycemia

F and E: ↑thirst

GI: ↑liver enzymes, nausea, anorexia, diarrhea, gingivitis, mouth ulcers, vomiting

GU: abnormal ejaculation, albuminuria, urinary retention

Hemat: eosinophilia

MS: joint disorder, neck pain

Neuro: headache, aggression, amnesia, anxiety, ataxia, cataplexy, confusion, delusions, depression, dizziness, dyskinesia, hallucinations, hypertonia, insomnia, mania, paresthesia, SEIZURES, SUICIDAL IDEATION, tremor

Resp: dyspnea

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA), infection

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Route/Dosage ⬆ ⬇

Hepatic Impairment

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Provigil

Canadian Brand Names ⬆ ⬇

Alertec

Contr. Subst. Schedule ⬆ ⬇

Schedule IV (C-IV)

Code ⬆

NDC Code