section name header

Pronunciation ⬇

rif-AM-pin

Classifications ⬆ ⬇

Therapeutic Classification: antituberculars

Pharmacologic Classification: rifamycins

Indications ⬆ ⬇

REMS

Unlabeled Use:
  • Prevention of disease caused by

    Haemophilus influenzae

    type B in close contacts.
  • Synergy with other antimicrobial agents for

    S. aureus

    infections.

Action ⬆ ⬇

  • Inhibits RNA synthesis by blocking RNA transcription in susceptible organisms.
Therapeutic effects:
  • Bactericidal action against susceptible organisms.

Spectrum:

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration.

Distribution: Widely distributed; enters CSF.

Protein Binding: 80%.

Metabolism/Excretion: Mostly metabolized by the liver; 60% eliminated in feces via biliary elimination.

Half-Life: 3 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTEONSETPEAKDURATION
POrapid2–4 hr12–24 hr
IVrapidend of infusion12–24 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), pruritus, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS

EENT: red discoloration of tears

GI: abdominal pain, diarrhea, flatulence, heartburn, nausea, vomiting, HEPATOTOXICITY, red discoloration of saliva and teeth

GU: red discoloration of urine

Hemat: bleeding, hemolytic anemia, thrombocytopenia, THROMBOTIC MICROANGIOPATHY (INCLUDING THROMBOTIC THROMBOCYTOPENIC PURPURA AND HEMOLYTIC UREMIA SYNDROME)

MS: arthralgia, muscle weakness, myalgia

Neuro: ataxia, confusion, drowsiness, fatigue, headache, weakness

Resp: INTERSTITIAL LUNG DISEASE

Misc: flu-like syndrome, HYPERSENSITIVITY REACTIONS (INCLUDING ANGIOEDEMA)

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Tuberculosis

Asymptomatic Carriers of Meningococcus

H. influenzae Prophylaxis

Synergy for S. aureus Infections

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

IV Administration:

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Rifadin, Rimactane

Canadian Brand Names ⬆ ⬇

Rofact

Code ⬆

NDC Code