fen-il-EFF-rin
Therapeutic Classification: vasopressors
Pharmacologic Classification: adrenergics, alpha adrenergic agonists, vasopressors
High Alert
Anesthesia adjunct
Absorption: Well absorbed from IM sites. IV administration results in complete bioavailability.
Distribution: Widely distributed to tissues.
Half-Life: 2.5 hr.
(vasopressor effects)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| IV | immediate | unknown | 15–20 min |
| IM | 10–15 min | unknown | 0.5–2 hr |
| SUBQ | 10–15 min | unknown | 50–60 min |
Contraindicated in:
Use Cautiously in:
CV: ARRHYTHMIAS, bradycardia, chest pain, hypertension, ischemia, tachycardia
Derm: pruritus
GI: epigastric pain, nausea, vomiting
Local: phlebitis, sloughing at IV sites
Neuro: blurred vision, headache, insomnia, nervousness, tremor
Resp: dyspnea
Drug-drug:
Hypotension
Hypotension During Anesthesia
Vasoconstrictor for Regional Anesthesia
Local
(Adults ): Add 1 mg to every 20 mL of local anesthetic (yields a 1:20,000 solution).Prolongation of Spinal Anesthesia
Spinal
(Adults ): 2–5 mg added to anesthetic solution.Patient harm and fatalities have occurred from medication errors with phenylephrine. Prior to administration, have second practitioner independently check original order, dose calculations, concentration, route of administration, and infusion pump settings.
IV Administration:
NDC Code