hye-drox-ee-KLOR-oh-kwin
REMS
Spectrum:
Absorption: Highly variable (31–100%) following oral administration.
Distribution: Widely distributed; high concentrations in RBCs; crosses the placenta; excreted into breast milk.
Half-Life: 40 days.
(plasma concentrations)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | rapid‡ | 1–2 hr | days–wk |
‡Onset of antirheumatic action may take 6 wk.
Contraindicated in:
Use Cautiously in:
CV: heart block, HF, QT interval prolongation, TORSADES DE POINTES
Derm: acute generalized exanthematous pustulosis, alopecia, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), ERYTHEMA MULTIFORME, hair color changes, hyperpigmentation, photosensitivity, pruritus, rash, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS, urticaria
EENT: corneal deposits, nystagmus, retinopathy, tinnitus, vertigo, visual disturbances
Endo: hypoglycemia
GI: ↑liver enzymes, abdominal pain, anorexia, diarrhea, HEPATOTOXICITY, nausea, vomiting
GU: proteinuria
Hemat: AGRANULOCYTOSIS, APLASTIC ANEMIA, leukopenia, thrombocytopenia
Neuro: aggressiveness, anxiety, ataxia, dizziness, dyskinesia, dystonia, fatigue, headache, irritability, neuromyopathy, nightmares, peripheral neuritis, personality changes, psychoses, SEIZURES, SUICIDAL THOUGHTS/BEHAVIORS, tremor
Resp: bronchospasm, PULMONARY HYPERTENSION
Misc: ANGIOEDEMA
Drug-drug:
Malaria
Rheumatoid Arthritis
Lupus Erythematosus
Lab Test Considerations:
NDC Code