section name header

Pronunciation

lev-am-LOE-di-peen

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: calcium channel blockers

Indications

REMS


Action

  • Inhibits the transport of calcium into myocardial and vascular smooth muscle cells, resulting primarily in peripheral arterial vasodilation.
Therapeutic effects:
  • Reduction in blood pressure.

Pharmacokinetics

Absorption: Well absorbed after oral administration (64–90%).

Distribution: Unknown.

Protein Binding: 93%.

Metabolism/Excretion: Mostly metabolized by the liver; primarily excreted in urine (10% as unchanged drug).

Half-Life: 30–50 hr.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POunknown6–12 hrunknown



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: peripheral edema, palpitations

Derm: flushing

GI: abdominal pain, nausea

Neuro: dizziness, drowsiness, fatigue

Interactions

Drug-drug:

Route/Dosage

Hepatic Impairment

Availability

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Conjupri