kar-ba-MAZ-e-peen
BEERS REMS
Equetro only
Absorption: Absorption is slow but complete. Suspension produces earlier, higher peak, and lower trough levels.
Distribution: Widely distributed. Crosses the blood-brain barrier. Crosses the placenta rapidly and enters breast milk in high concentrations.
Protein Binding: Carbamazepine: 75–90%; epoxide: 50%.
Half-Life: Carbamazepine: single dose—25–65 hr, chronic dosing—Children: 8–14 hr; Adults: 12–17 hr; epoxide: 34±9 hr.
(anticonvulsant activity)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | up to 1 mo‡ | 4–5 hr‡ | 6–12 hr |
| PO-ER | up to 1 mo‡ | 2–3–12 hr‡ | 12 hr |
‡Onset of antineuralgic activity is 8–72 hr.
‡Listed for tablets; peak level occurs 1.5 hr after a chronic dose of suspension.
Contraindicated in:
Use Cautiously in:
CV: HF, edema, heart block, hypertension, hypotension, syncope
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), nail shedding, photosensitivity, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, urticaria
EENT: blurred vision, corneal opacities, nystagmus
Endo: SIADH
F and E: hyponatremia
GI: ↑liver enzymes, HEPATOTOXICITY, PANCREATITIS
GU: hesitancy, urinary retention
Hemat: AGRANULOCYTOSIS, APLASTIC ANEMIA, eosinophilia, leukopenia, lymphadenopathy, THROMBOCYTOPENIA
Neuro: ataxia, drowsiness, fatigue, psychosis, sedation, SUICIDAL THOUGHTS, vertigo
Resp: pneumonitis
Misc: chills, fever
Drug-drug:
Seizures
Trigeminal Neuralgia
Acute Manic or Mixed Episodes Associated with Bipolar I Disorder
Lab Test Considerations:
Toxicity and Overdose:
NDC Code