i-pra-TROE-pee-um
Therapeutic Classification: allergy, cold and cough remedies, bronchodilators
Pharmacologic Classification: anticholinergics
REMS
Absorption: Minimal systemic absorption (2% for inhalation solution; 20% for inhalation aerosol; <20% following nasal use).
Distribution: 15% of dose reaches lower airways after inhalation.
Half-Life: 2 hr.
Contraindicated in:
Use Cautiously in:
CV: hypotension, palpitations
Derm: rash
EENT: blurred vision, sore throat,
nasal only
epistaxis, nasal dryness/irritationGI: GI irritation, nausea
Neuro: dizziness, headache, nervousness
Resp: bronchospasm, cough
Drug-drug:
Inhaln
(Adults and Children >12 yr): Metered-dose inhaler (nonacute): 2 inhalations 4 times daily (not to exceed 12 inhalations/24 hr or more frequently than every 4 hr). Acute exacerbations: 4–8 puffs using a spacer device as needed. Via nebulization (nonacute): 500 mcg 3–4 times daily. Via nebulization (acute exacerbations): 500 mcg every 30 min for 3 doses, then every 2–4 hr as needed.Inhaln
(Adults and Children 5–12 yr): Metered-dose inhaler (nonacute): 1–2 inhalations every 6 hr as needed (not to exceed 12 inhalations/24 hr). Acute exacerbations: 4–8 puffs as needed. Via nebulization (nonacute): 250–500 mcg 4 times daily given every 6 hr. Acute exacerbations: 250 mcg every 20 min for 3 doses, then every 2–4 hr as needed.Inhaln
(Infants ): Nebulization: 125–250 mcg 3 times a day.Inhaln
(Neonates ): Nebulization: 25 mcg/kg/dose 3 times a day.Inhaln
(Adults and Children >5 yr): 0.06% solution: 2 sprays in each nostril 3–4 times daily (42 mcg/spray).NDC Code