Therapeutic Classification: antiretrovirals
Pharmacologic Classification: nucleoside reverse transcriptase inhibitors
Absorption: Tenofovir disoproxil fumarate is a prodrug, which is split into tenofovir, the active component. Absorption enhanced by food.
Distribution: Minimally distributed to extravascular tissues.
Half-Life: Unknown.
Contraindicated in:
Use Cautiously in:
Derm: rash
F and E: hypophosphatemia
GI: diarrhea, nausea, abdominal pain, anorexia, flatulence, LACTIC ACIDOSIS/HEPATOMEGALY WITH STEATOSIS, vomiting
GU: ACUTE RENAL FAILURE/FANCONI SYNDROME, proximal renal tubulopathy, renal impairment
MS: ↓bone mineral density, bone pain, muscle pain, osteomalacia
Neuro: depression, headache, weakness
Misc: immune reconstitution syndrome
Drug-drug:
Tablets:
2834.9 kg: 250 mg once daily; 2227.9 kg: 200 mg once daily; 1721.9 kg: 150 mg once daily.Oral Powder:
3434.9 kg: 7 scoops (280 mg) once daily; 3233.9 kg: 6.5 scoops (260 mg) once daily; 2931.9 kg: 6 scoops (240 mg) once daily; 2728.9 kg: 5.5 scoops (220 mg) once daily; 2426.9 kg: 5 scoops (200 mg) once daily; 2223.9 kg: 4.5 scoops (180 mg) once daily; 1921.9 kg: 4 scoops (160 mg) once daily; 1718.9 kg: 3.5 scoops (140 mg) once daily; 1416.9 kg: 3 scoops (120 mg) once daily; 1213.9 kg: 2.5 scoops (100 mg) once daily; 1011.9 kg: 2 scoops (80 mg) once daily.Renal Impairment
Lab Test Considerations: