Absorption: 25% absorbed following oral administration (much inter-individual variability).
Distribution: Crosses the placenta; may enter breast milk.
Half-Life: 12 hr (↑ in renal impairment).
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | 1 hr | 6 hr | 24 hr |
‡Full effects may not be noted for several weeks.
Contraindicated in:
Use Cautiously in:
CV: hypotension, chest pain
Derm: rash
F and E: hyperkalemia
GI: abdominal pain, diarrhea, nausea, vomiting
GU: erectile dysfunction, renal impairment
Neuro: dizziness, fatigue, headache, weakness
Resp: cough
Misc: ANGIOEDEMA
Drug-drug:
Hypertension
Renal Impairment
Renal Impairment
Renal Impairment
Acute Myocardial Infarction
Renal Impairment
Lab Test Considerations:
NDC Code