section name header

Pronunciation

bis-a-KOE-dill

Classifications

Therapeutic Classification: laxatives

Pharmacologic Classification: stimulant laxatives

Indications

REMS


Action

  • Stimulates peristalsis.
  • Alters fluid and electrolyte transport, producing fluid accumulation in the colon.
Therapeutic effects:
  • Evacuation of the colon.

Pharmacokinetics

Absorption: Variable absorption follows oral administration; rectal absorption is minimal; action is local in the colon.

Distribution: Small amounts of metabolites excreted in breast milk.

Metabolism/Excretion: Small amounts absorbed are metabolized by the liver.

Half-Life: Unknown.

Time/Action Profile

(evacuation of bowel)

ROUTEONSETPEAKDURATION
PO6–12 hrunknownunknown
Rectal15–60 minunknownunknown



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

F and E: hypokalemia (with chronic use)

GI: abdominal cramps, nausea, diarrhea, rectal burning

MS: muscle weakness (with chronic use)

Misc: protein-losing enteropathy, tetany (with chronic use)

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Dulcolax, Ex-Lax Ultra

Code

NDC Code