kar-boe-PLA-tin
High Alert
Absorption: IV administration results in complete bioavailability.
Distribution: Well distributed to tissues.
Protein Binding: Platinum is irreversibly bound to plasma proteins.
Half-Life: Carboplatin: 2.6–5.9 hr (↑ in renal impairment); platinum: 5 days.
Contraindicated in:
Use Cautiously in:
Derm: alopecia, rash
EENT: ototoxicity
F and E: hypocalcemia, hypokalemia, hypomagnesemia, hyponatremia
GI: abdominal pain, nausea, vomiting, constipation, diarrhea, hepatitis, stomatitis
GU: gonadal suppression, nephrotoxicity
Hemat: ANEMIA, LEUKOPENIA, THROMBOCYTOPENIA
Neuro: peripheral neuropathy, weakness
Drug-drug:
Renal Impairment
Lab Test Considerations:
Fatalities have occurred with chemotherapeutic agents. Before administering, clarify all ambiguous orders; double-check single, daily, and course-of-therapy dose limits; have second practitioner independently double-check original order, calculations, and infusion pump settings.
Do not confuse carboplatin with cisplatin.
Carboplatin should be administered in a monitored setting under the supervision of a physician experienced in cancer chemotherapy.
IV Administration:
NDC Code