section name header

Pronunciation ⬇

SIL-ver sul-fa-DYE-a-zeen

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives (topical)

Pharmacologic Classification: sulfonamides

Indications ⬆ ⬇

REMS

Unlabeled Use:
  • Management of:
    • Minor skin infections,
    • Dermal ulcers.

Action ⬆ ⬇

  • Splits to produce bactericidal concentrations of silver and sulfadiazine.
  • Action is at level of cell membrane and cell wall.
Therapeutic effects:
  • Bactericidal action against organisms found in burns.

Spectrum:

Pharmacokinetics ⬆ ⬇

Absorption: Small amounts of silver are systemically absorbed following topical application. Up to 10% of sulfadiazine is absorbed.

Distribution: Unknown.

Metabolism/Excretion: Absorbed sulfadiazine is excreted unchanged by the kidneys.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(anti-infective action)

ROUTEONSETPEAKDURATION
Topicalon contactunknownas long as applied



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: burning, EXFOLIATIVE DERMATITIS, itching, pain, rash, skin discoloration, skin necrosis, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS

Hemat: leukopenia

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Flint SSD, Sildimac, Silvadene, Thermazene

Canadian Brand Names ⬆ ⬇

Dermazin, Flamazine

Code ⬆

NDC Code