diphenoxylate/atropine

section name header

Pronunciation ⬇

diphenoxylate/atropine: dye-fen-OX-i-late/A-troe-peen

difenoxin/atropine : dye-fen-OX-in/A-troe-peen

Classifications ⬆ ⬇

Therapeutic Classification: antidiarrheals

Pharmacologic Classification: anticholinergics

Indications ⬆ ⬇

REMS

Adjunctive therapy in the treatment of diarrhea.

Action ⬆ ⬇

Inhibits excess GI motility.
Structurally related to opioid analgesics but has no analgesic properties.
Atropine added to discourage abuse.

Therapeutic effects:

Decreased GI motility with subsequent decrease in diarrhea.

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed from the GI tract.

Distribution: Enters breast milk.

Metabolism/Excretion: Diphenoxylate: Mostly metabolized by the liver with some conversion to an active antidiarrheal compound (difenoxin). Difenoxin: Metabolized by the liver. Minimal excretion in urine.

Half-Life: Diphenoxylate: 2.5 hr; difenoxin: 4.5 hr.

Time/Action Profile ⬆ ⬇

(antidiarrheal action)

ROUTE	ONSET	PEAK	DURATION
Difenoxin-PO	45–60 min	2 hr	3–4 hr
Diphenoxylate-PO	45–60 min	2 hr	3–4 hr

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity;
Severe liver disease;
Infectious diarrhea (due to Escherichia coli, Salmonella, or Shigella);
Diarrhea associated with Clostridioides difficile-associated diarrhea;
Dehydration;
Angle-closure glaucoma;
Pedi: Children <2 yr (for diphenoxylate/atropine).

Use Cautiously in:

Physical dependence on opioids;
Inflammatory bowel disease;
Prostatic hyperplasia;
OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding;
Pedi: Children <12 yr (safety and effectiveness of difenoxin/atropine not established);
Geri: Older adults more sensitive to effects.

Adv. Reactions/Side Effects ⬆ ⬇

CV: tachycardia

Derm: flushing

EENT: blurred vision, dry eyes

GI: constipation, dry mouth, epigastric distress, ileus, nausea, vomiting

GU: urinary retention

Neuro: dizziness, confusion, drowsiness, headache, insomnia, nervousness

Interactions ⬆ ⬇

Drug-drug:

Additive CNS depression with other CNS depressants, including alcohol, antihistamines, opioid analgesics, and sedative/hypnotics.
Additive anticholinergic properties with other drugs having anticholinergic properties, including tricyclic antidepressants and disopyramide.
Use with MAO inhibitors may result in hypertensive crisis.

Drug-Natural Products:

↑anticholinergic effects with angel’s trumpet, jimson weed, and scopolia.

Route/Dosage ⬆ ⬇

Difenoxin/Atropine

Doses given are in terms of difenoxin; each tablet contains 1 mg difenoxin with 0.025 mg of atropine
PO (Adults ): 2 tablets initially; then 1 tablet after each loose stool or every 3–4 hr as needed (not to exceed 8 tablets/day).

Diphenoxylate/Atropine

PO (Adults ): 5 mg of diphenoxylate 3–4 times daily initially; then 5 mg of diphenoxylate once daily as needed (not to exceed 20 mg/day).

Availability ⬆ ⬇

Difenoxin/Atropine

Tablets: 1 mg difenoxin/0.025 mg atropine

Diphenoxylate/Atropine

(Generic available)

Tablets: 2.5 mg diphenoxylate/0.025 mg atropine

Assessment ⬆ ⬇

Assess the frequency and consistency of stools and bowel sounds before and throughout therapy.
Assess for hypotension, respiratory depression, and atropinism (dryness of skin and mucous membranes, tachycardia, thirst, flushing).
Assess for fluid and electrolyte imbalances and skin turgor for dehydration.

Lab Test Considerations:

Monitor liver function tests periodically during prolonged therapy.
- May ↑ serum amylase concentrations.

Implementation ⬆ ⬇

Risk of dependence ↑ with high-dose, long-term use. Atropine has been added to discourage abuse.
PO: Administer with or without food. Tablets may be crushed and administered with patient's choice of fluid.

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Instruct patient to take as directed. Do not take more than the prescribed amount because of the habit-forming potential and risk of overdose in children. If on a scheduled dosing regimen, missed doses should be taken as soon as possible unless almost time for next dose. Do not double doses. Advise patient that treatment of acute diarrhea should be continued for 24–36 hr before it is considered ineffective.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
Medication may cause drowsiness. Advise patient to avoid driving or other activities requiring alertness until response to drug is known.
Advise patient that frequent mouth rinses, good oral hygiene, and sugarless gum or candy may relieve dry mouth.
Caution patient to avoid alcohol and other CNS depressants concurrently with this medication.
Advise patient to inform health care professional of medication regimen prior to treatment or surgery.
Instruct patient to notify health care professional if diarrhea persists or if fever, abdominal pain, or palpitations occur.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes ⬆ ⬇

Decreased GI motility with subsequent decrease in diarrhea.

US Brand Names ⬆ ⬇

diphenoxylate/atropine: Lomotil,

difenoxin/atropine : Motofen

Contr. Subst. Schedule ⬆ ⬇

Schedule V (C-V)diphenoxylate/atropine
Schedule IV (C-IV)difenoxin/atropine

Code ⬆

NDC Code

0025- G.D. Searle LLC Division of Pfizer Inc
- 0025-0061- Lomotil
  - 0025-0061-31- 100 TABLET in 1 BOTTLE (0025-0061-31)

0054- West-Ward Pharmaceuticals Corp.
- 0054-3194- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 0054-3194-46- 1 BOTTLE, DROPPER in 1 CARTON (0054-3194-46) > 60 mL in 1 BOTTLE, DROPPER

0378- Mylan Pharmaceuticals Inc.
- 0378-0415- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 0378-0415-01- 100 TABLET in 1 BOTTLE, PLASTIC (0378-0415-01)

0378- Mylan Pharmaceuticals Inc.
- 0378-0415- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 0378-0415-10- 1000 TABLET in 1 BOTTLE, PLASTIC (0378-0415-10)

0378- Mylan Pharmaceuticals Inc.
- 0378-0415- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 0378-0415-77- 90 TABLET in 1 BOTTLE, PLASTIC (0378-0415-77)

0527- Lannett Company, Inc.
- 0527-1170- DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE
  - 0527-1170-01- 100 TABLET in 1 BOTTLE (0527-1170-01)

0527- Lannett Company, Inc.
- 0527-1170- DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE
  - 0527-1170-05- 500 TABLET in 1 BOTTLE (0527-1170-05)

0527- Lannett Company, Inc.
- 0527-1170- DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE
  - 0527-1170-10- 1000 TABLET in 1 BOTTLE (0527-1170-10)

0832- Upsher-Smith Laboratories, LLC
- 0832-0590- Diphenoxylate hydrochloride and atropine sulfate
  - 0832-0590-10- 1000 TABLET in 1 BOTTLE (0832-0590-10)

0832- Upsher-Smith Laboratories, LLC
- 0832-0590- Diphenoxylate hydrochloride and atropine sulfate
  - 0832-0590-11- 100 TABLET in 1 BOTTLE (0832-0590-11)

0832- Upsher-Smith Laboratories, LLC
- 0832-0590- Diphenoxylate hydrochloride and atropine sulfate
  - 0832-0590-90- 90 TABLET in 1 BOTTLE (0832-0590-90)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-00- 10 TABLET in 1 BOTTLE (12634-531-00)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-50- 50 TABLET in 1 BOTTLE (12634-531-50)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-54- 14 TABLET in 1 BLISTER PACK (12634-531-54)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-55- 15 TABLET in 1 BLISTER PACK (12634-531-55)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-59- 30 TABLET in 1 BLISTER PACK (12634-531-59)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-60- 60 TABLET in 1 BOTTLE (12634-531-60)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-61- 10 TABLET in 1 BLISTER PACK (12634-531-61)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-79- 25 TABLET in 1 BOTTLE (12634-531-79)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-80- 20 TABLET in 1 BOTTLE (12634-531-80)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-82- 12 TABLET in 1 BOTTLE (12634-531-82)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-91- 1 TABLET in 1 BLISTER PACK (12634-531-91)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-95- 5 TABLET in 1 BOTTLE (12634-531-95)

12634- Apotheca Inc.
- 12634-531- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 12634-531-97- 7 TABLET in 1 BOTTLE (12634-531-97)

33261- Aidarex Pharmaceuticals LLC
- 33261-685- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 33261-685-15- 15 TABLET in 1 BOTTLE, PLASTIC (33261-685-15)

33261- Aidarex Pharmaceuticals LLC
- 33261-685- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 33261-685-30- 30 TABLET in 1 BOTTLE, PLASTIC (33261-685-30)

43063- PD-Rx Pharmaceuticals, Inc.
- 43063-089- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43063-089-04- 4 TABLET in 1 BOTTLE, PLASTIC (43063-089-04)

43063- PD-Rx Pharmaceuticals, Inc.
- 43063-089- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43063-089-06- 6 TABLET in 1 BOTTLE, PLASTIC (43063-089-06)

43063- PD-Rx Pharmaceuticals, Inc.
- 43063-957- Diphenoxylate hydrochloride and atropine sulfate
  - 43063-957-04- 4 TABLET in 1 BOTTLE, PLASTIC (43063-957-04)

43063- PD-Rx Pharmaceuticals, Inc.
- 43063-957- Diphenoxylate hydrochloride and atropine sulfate
  - 43063-957-10- 10 TABLET in 1 BOTTLE, PLASTIC (43063-957-10)

43063- PD-Rx Pharmaceuticals, Inc.
- 43063-957- Diphenoxylate hydrochloride and atropine sulfate
  - 43063-957-15- 15 TABLET in 1 BOTTLE, PLASTIC (43063-957-15)

43063- PD-Rx Pharmaceuticals, Inc.
- 43063-957- Diphenoxylate hydrochloride and atropine sulfate
  - 43063-957-20- 20 TABLET in 1 BOTTLE, PLASTIC (43063-957-20)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-083- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-083-30- 30 TABLET in 1 BOTTLE (43353-083-30)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-083- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-083-53- 60 TABLET in 1 BOTTLE (43353-083-53)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-083- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-083-60- 90 TABLET in 1 BOTTLE (43353-083-60)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-083- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-083-70- 120 TABLET in 1 BOTTLE (43353-083-70)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-083- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-083-80- 180 TABLET in 1 BOTTLE (43353-083-80)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-083- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-083-90- 240 TABLET in 1 BOTTLE (43353-083-90)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-594- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-594-30- 30 TABLET in 1 BOTTLE (43353-594-30)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-594- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-594-53- 60 TABLET in 1 BOTTLE (43353-594-53)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-594- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-594-60- 90 TABLET in 1 BOTTLE (43353-594-60)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-594- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-594-70- 120 TABLET in 1 BOTTLE (43353-594-70)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-594- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-594-80- 180 TABLET in 1 BOTTLE (43353-594-80)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-594- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 43353-594-90- 240 TABLET in 1 BOTTLE (43353-594-90)

50090- A-S Medication Solutions
- 50090-0039- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-0039-0- 15 TABLET in 1 BOTTLE, PLASTIC (50090-0039-0)

50090- A-S Medication Solutions
- 50090-0039- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-0039-1- 20 TABLET in 1 BOTTLE, PLASTIC (50090-0039-1)

50090- A-S Medication Solutions
- 50090-0039- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-0039-2- 30 TABLET in 1 BOTTLE, PLASTIC (50090-0039-2)

50090- A-S Medication Solutions
- 50090-0040- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-0040-0- 20 TABLET in 1 BOTTLE, PLASTIC (50090-0040-0)

50090- A-S Medication Solutions
- 50090-2641- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-2641-0- 20 TABLET in 1 BOTTLE (50090-2641-0)

50090- A-S Medication Solutions
- 50090-2872- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-2872-0- 15 TABLET in 1 BOTTLE (50090-2872-0)

50090- A-S Medication Solutions
- 50090-2872- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-2872-1- 20 TABLET in 1 BOTTLE (50090-2872-1)

50090- A-S Medication Solutions
- 50090-2872- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-2872-2- 30 TABLET in 1 BOTTLE (50090-2872-2)

50090- A-S Medication Solutions
- 50090-3452- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-3452-0- 20 TABLET in 1 BOTTLE (50090-3452-0)

50090- A-S Medication Solutions
- 50090-3456- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-3456-0- 15 TABLET in 1 BOTTLE (50090-3456-0)

50090- A-S Medication Solutions
- 50090-3456- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-3456-1- 20 TABLET in 1 BOTTLE, PLASTIC (50090-3456-1)

50090- A-S Medication Solutions
- 50090-3456- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 50090-3456-2- 30 TABLET in 1 BOTTLE (50090-3456-2)

53002- RPK Pharmaceuticals, Inc.
- 53002-3400- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 53002-3400-1- 10 TABLET in 1 BOTTLE (53002-3400-1)

53002- RPK Pharmaceuticals, Inc.
- 53002-3400- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 53002-3400-2- 20 TABLET in 1 BOTTLE (53002-3400-2)

55289- PD-Rx Pharmaceuticals, Inc.
- 55289-102- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 55289-102-10- 10 TABLET in 1 BOTTLE, PLASTIC (55289-102-10)

55289- PD-Rx Pharmaceuticals, Inc.
- 55289-102- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 55289-102-15- 15 TABLET in 1 BOTTLE, PLASTIC (55289-102-15)

55289- PD-Rx Pharmaceuticals, Inc.
- 55289-102- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 55289-102-20- 20 TABLET in 1 BOTTLE, PLASTIC (55289-102-20)

55289- PD-Rx Pharmaceuticals, Inc.
- 55289-102- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 55289-102-30- 30 TABLET in 1 BOTTLE, PLASTIC (55289-102-30)

55700- Lake Erie Medical DBA Quality Care Products LLC
- 55700-255- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 55700-255-20- 20 TABLET in 1 BOTTLE (55700-255-20)

59762- Greenstone LLC
- 59762-1061- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 59762-1061-1- 100 TABLET in 1 BOTTLE (59762-1061-1)

59762- Greenstone LLC
- 59762-1061- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 59762-1061-2- 1000 TABLET in 1 BOTTLE (59762-1061-2)

61919- DIRECT RX
- 61919-405- DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE
  - 61919-405-20- 20 TABLET in 1 BOTTLE (61919-405-20)

61919- DIRECT RX
- 61919-405- DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE
  - 61919-405-30- 30 TABLET in 1 BOTTLE (61919-405-30)

62559- ANI Pharmaceuticals, Inc.
- 62559-490- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 62559-490-01- 100 TABLET in 1 BOTTLE (62559-490-01)

62559- ANI Pharmaceuticals, Inc.
- 62559-490- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 62559-490-10- 1000 TABLET in 1 BOTTLE (62559-490-10)

63187- Proficient Rx LP
- 63187-254- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-254-15- 15 TABLET in 1 BOTTLE, PLASTIC (63187-254-15)

63187- Proficient Rx LP
- 63187-254- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-254-20- 20 TABLET in 1 BOTTLE, PLASTIC (63187-254-20)

63187- Proficient Rx LP
- 63187-254- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-254-30- 30 TABLET in 1 BOTTLE, PLASTIC (63187-254-30)

63187- Proficient Rx LP
- 63187-254- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-254-60- 60 TABLET in 1 BOTTLE, PLASTIC (63187-254-60)

63187- Proficient Rx LP
- 63187-254- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-254-90- 90 TABLET in 1 BOTTLE, PLASTIC (63187-254-90)

63187- Proficient Rx LP
- 63187-939- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-939-10- 10 TABLET in 1 BOTTLE (63187-939-10)

63187- Proficient Rx LP
- 63187-939- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-939-15- 15 TABLET in 1 BOTTLE (63187-939-15)

63187- Proficient Rx LP
- 63187-939- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-939-20- 20 TABLET in 1 BOTTLE (63187-939-20)

63187- Proficient Rx LP
- 63187-939- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-939-30- 30 TABLET in 1 BOTTLE (63187-939-30)

63187- Proficient Rx LP
- 63187-939- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-939-60- 60 TABLET in 1 BOTTLE (63187-939-60)

63187- Proficient Rx LP
- 63187-939- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 63187-939-90- 90 TABLET in 1 BOTTLE (63187-939-90)

66267- NuCare Pharmaceuticals, Inc.
- 66267-082- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 66267-082-20- 20 TABLET in 1 BOTTLE, PLASTIC (66267-082-20)

66267- NuCare Pharmaceuticals, Inc.
- 66267-780- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 66267-780-04- 4 TABLET in 1 BOTTLE (66267-780-04)

67296- RedPharm Drug, Inc.
- 67296-1572- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 67296-1572-1- 15 TABLET in 1 BOTTLE (67296-1572-1)

67296- RedPharm Drug, Inc.
- 67296-1675- DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE
  - 67296-1675-3- 15 TABLET in 1 BOTTLE (67296-1675-3)

67544- Aphena Pharma Solutions - Tennessee, LLC
- 67544-021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 67544-021-30- 30 TABLET in 1 BOTTLE, PLASTIC (67544-021-30)

67544- Aphena Pharma Solutions - Tennessee, LLC
- 67544-021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 67544-021-40- 40 TABLET in 1 BOTTLE, PLASTIC (67544-021-40)

67544- Aphena Pharma Solutions - Tennessee, LLC
- 67544-021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 67544-021-53- 60 TABLET in 1 BOTTLE, PLASTIC (67544-021-53)

67544- Aphena Pharma Solutions - Tennessee, LLC
- 67544-021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 67544-021-60- 90 TABLET in 1 BOTTLE, PLASTIC (67544-021-60)

67544- Aphena Pharma Solutions - Tennessee, LLC
- 67544-021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 67544-021-70- 120 TABLET in 1 BOTTLE, PLASTIC (67544-021-70)

67544- Aphena Pharma Solutions - Tennessee, LLC
- 67544-021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 67544-021-80- 180 TABLET in 1 BOTTLE, PLASTIC (67544-021-80)

67544- Aphena Pharma Solutions - Tennessee, LLC
- 67544-021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 67544-021-90- 240 TABLET in 1 BOTTLE, PLASTIC (67544-021-90)

68071- NuCare Pharmaceuticals,Inc.
- 68071-4063- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 68071-4063-1- 10 TABLET in 1 BOTTLE (68071-4063-1)

68071- NuCare Pharmaceuticals,Inc.
- 68071-4063- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 68071-4063-2- 20 TABLET in 1 BOTTLE (68071-4063-2)

68071- NuCare Pharmaceuticals,Inc.
- 68071-4063- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 68071-4063-3- 30 TABLET in 1 BOTTLE (68071-4063-3)

68071- NuCare Pharmaceuticals,Inc.
- 68071-4063- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 68071-4063-5- 15 TABLET in 1 BOTTLE (68071-4063-5)

68788- Preferred Pharmaceuticals Inc.
- 68788-7021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 68788-7021-1- 10 TABLET in 1 BOTTLE (68788-7021-1)

68788- Preferred Pharmaceuticals Inc.
- 68788-7021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 68788-7021-2- 20 TABLET in 1 BOTTLE (68788-7021-2)

68788- Preferred Pharmaceuticals Inc.
- 68788-7021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 68788-7021-3- 30 TABLET in 1 BOTTLE (68788-7021-3)

68788- Preferred Pharmaceuticals Inc.
- 68788-7021- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 68788-7021-7- 21 TABLET in 1 BOTTLE (68788-7021-7)

70166- Lohxa
- 70166-630- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 70166-630-01- 12 BAG in 1 BOX (70166-630-01) > 1 SYRINGE in 1 BAG > 5 mL in 1 SYRINGE

70518- REMEDYREPACK INC.
- 70518-0919- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 70518-0919-0- 30 TABLET in 1 BLISTER PACK (70518-0919-0)

70518- REMEDYREPACK INC.
- 70518-2135- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 70518-2135-0- 30 TABLET in 1 BLISTER PACK (70518-2135-0)

71335- Bryant Ranch Prepack
- 71335-0311- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 71335-0311-1- 20 TABLET in 1 BOTTLE (71335-0311-1)

71335- Bryant Ranch Prepack
- 71335-0311- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 71335-0311-2- 30 TABLET in 1 BOTTLE (71335-0311-2)

71335- Bryant Ranch Prepack
- 71335-0311- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 71335-0311-3- 15 TABLET in 1 BOTTLE (71335-0311-3)

71335- Bryant Ranch Prepack
- 71335-0311- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 71335-0311-4- 10 TABLET in 1 BOTTLE (71335-0311-4)

71335- Bryant Ranch Prepack
- 71335-0311- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 71335-0311-5- 40 TABLET in 1 BOTTLE (71335-0311-5)

71335- Bryant Ranch Prepack
- 71335-0311- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 71335-0311-6- 60 TABLET in 1 BOTTLE (71335-0311-6)

71335- Bryant Ranch Prepack
- 71335-0311- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 71335-0311-7- 90 TABLET in 1 BOTTLE (71335-0311-7)

76385- Bayshore Pharmaceuticals, LLC
- 76385-107- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 76385-107-01- 100 TABLET in 1 BOTTLE (76385-107-01)

76385- Bayshore Pharmaceuticals, LLC
- 76385-107- Diphenoxylate Hydrochloride and Atropine Sulfate
  - 76385-107-10- 1000 TABLET in 1 BOTTLE (76385-107-10)