REMS
Spectrum:
Absorption: Well absorbed (99%) after oral administration; IV administration results in complete bioavailability.
Distribution: Widely distributed. High tissue and urinary levels are achieved. Appears to cross the placenta.
Protein Binding: 2438%
Half-Life: 8 hr.
Contraindicated in:
Use Cautiously in:
CV: QT interval prolongation, AORTIC ANEURYSM/DISSECTION, TORSADES DE POINTES
Derm: acute generalized exanthematous pustulosis, photosensitivity, rash, STEVENS-JOHNSON SYNDROME
Endo: hyperglycemia, hypoglycemia
GI: nausea, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), abdominal pain, diarrhea, HEPATOTOXICITY, vomiting
GU: vaginitis
Local: phlebitis at IV site
MS: arthralgia, myalgia, tendinitis, tendon rupture
Neuro: agitation, anxiety, confusion, depression, dizziness, ELEVATED INTRACRANIAL PRESSURE (INCLUDING PSEUDOTUMOR CEREBRI), hallucinations, headache, insomnia, lightheadedness, nightmares, paranoia, peripheral neuropathy, SEIZURES, SUICIDAL THOUGHTS/BEHAVIORS, toxic psychosis, tremor
Drug-drug:
Nosocomial Pneumonia
Community-Acquired Pneumonia
Skin/Skin Structure Infections
Chronic Bacterial Prostatitis
Inhalational Anthrax (Post-Exposure)
Plague
Urinary Tract Infections
Acute Bacterial Exacerbations of Chronic Bronchitis
Acute Sinusitis
Renal Impairment
Clostridioides difficile
-associated diarrhea (CDAD). May begin up to several wk following cessation of therapy.Lab Test Considerations:
Y-Site Incompatibility:
IV Administration:
NDC Code