ter-BI-na-feen
Spectrum:
Absorption: 70–80% absorbed after oral administration.
Distribution: Extensively distributed; penetrates dermis and epidermis; concentrates in stratum corneum, hair, scalp, and nails. Enters breast milk.
Protein Binding: 99%.
Half-Life: Plasma—22 days; longer from skin and nails.
Contraindicated in:
Use Cautiously in:
CV: heart failure
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, itching, rash
GI: HEPATOTOXICITY, anorexia, diarrhea, nausea, stomach pain, vomiting, drug-induced hepatitis, smell disturbance, taste disturbance
Hemat: hemolytic uremic syndrome, neutropenia, pancytopenia, thrombotic thrombocytopenic purpura
Neuro: depression, headache
Resp: cough, nasopharyngitis
Misc: fever
Drug-drug:
Drug-Natural Products:
Lab Test Considerations:
NDC Code