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Therapeutic Classification: hemostatic agents
Pharmacologic Classification: clotting factors replacements
Absorption: IV administration results in complete bioavailability.
Distribution: Unknown.
Metabolism/Excretion: Used up in clotting process.
Half-Life: Adults: 86.5 hr; children 12–17 yr: 84 hr; children 6–11 yr: 72.2 hr; children 2–5 yr: 66.4 hr.
(decreased bleeding/risk of bleeding)
| ROUTE | ONSET | PEAK | DURATION |
|---|
| IV | rapid | unknown | 6–48 hr ‡ |
One unit/kg increases circulating Factor IX (FIX) level by 1%.
- IV (Adults and Children ): Minor and moderate bleeding: amount needed to produce a circulating FIX level of 30–40 IU/dL, repeated every 48 hr as needed; Major bleeding: amount needed to produce a circulating FIX level of 80–100 IU/dL, repeat after 6–10 hr, then every 24 hr for three days, then every 48 hr until healing occurs; Perioperative management (minor procedures): amount needed to produce a circulating FIX level of 50–80 IU/dL as a single infusion, may be repeated after 24–48 hr until bleeding ceases and healing has occurs; Perioperative management (major procedures): amount needed to produce a circulating FIX level of 60–100 IU/dL as a single infusion, may be repeated after 6–10 hr and then every 24 for 3 days until bleeding ceases and healing occurs (additional doses may be given every 48 hr if needed);Routine prophylaxis: 50 IU/kg once weekly or 100 IU/kg every 10 days. Doses may be modified according to need/response.