section name header

Pronunciation ⬇

fa-MOE-ti-deen

Classifications ⬆ ⬇

Therapeutic Classification: antiulcer agents

Pharmacologic Classification: histamine h2 antagonists

Indications ⬆ ⬇

REMS

Unlabeled Use:
  • GI symptoms associated with the use of NSAIDs.
  • Prevention of stress ulceration or aspiration pneumonitis.
  • Management of urticaria.

Action ⬆ ⬇

  • Inhibits the action of histamine at the H2-receptor site located primarily in gastric parietal cells, resulting in inhibition of gastric acid secretion.
Therapeutic effects:
  • Healing and prevention of ulcers.
  • Decreased symptoms of GERD.
  • Decreased secretion of gastric acid.

Pharmacokinetics ⬆ ⬇

Absorption: 40–45% absorbed following oral administration.

Distribution: Enters cerebrospinal fluid.

Metabolism/Excretion: Up to 70% excreted unchanged by the kidneys, 30–35% metabolized by the liver.

Half-Life: Infants: 4.5–15 hr; Children: 3.3–5.7 hr; Adults: 2.5–3.5 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
POwithin 60 min1–4 hr6–12 hr
IVwithin 60 min0.5–3 hr8–15 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: ARRHYTHMIAS

Endo: gynecomastia

GI: constipation, diarrhea, nausea

GU: ↓sperm count, erectile dysfunction

Hemat: AGRANULOCYTOSIS, APLASTIC ANEMIA, anemia, neutropenia, thrombocytopenia

Neuro: confusion, dizziness, drowsiness, hallucinations, headache

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Renal Impairment

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

IV Administration:

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Pepcid, Pepcid AC

Code ⬆

NDC Code