Therapeutic Classification: antirheumatics (DMARDs)
Pharmacologic Classification: fusion proteins
Absorption: IV administration results in complete bioavailability.
Distribution: Unknown.
Metabolism/Excretion: Unknown.
Half-Life: 13 days.
(improvement in symptoms)
| ROUTE | ONSET | PEAK | DURATION |
|---|
| IV | within 15 days–3 mo | 6–12 mo | 3 yr (maintenance of response) |
Rheumatoid Arthritis
- IV (Adults >100 kg): 1000 mg initially; repeat dose at 2 wk and 4 wk after initial dose, then every 4 wk thereafter.
- IV (Adults 60–100 kg): 750 mg initially; repeat dose at 2 wk and 4 wk after initial dose, then every 4 wk thereafter.
- IV (Adults <60 kg): 500 mg initially; repeat dose at 2 wk and 4 wk after initial dose, then every 4 wk thereafter.
- SC (Adults ): Treatment may be initiated with or without a single IV dose (according to weight-based dosing guidelines above); then give 125 mg SUBQ within 1 day; then give 125 mg SUBQ once weekly; if patient does not receive IV dose, initiate once weekly SUBQ injections; if transitioning from IV therapy, administer next scheduled dose as SUBQ injection.
Juvenile Idiopathic Arthritis
- IV (Children ≥6 yr and >100 kg): 1000 mg initially; repeat dose at 2 wk and 4 wk after initial dose, then every 4 wk thereafter.
- IV (Children ≥6 yr and 75–100 kg): 750 mg initially; repeat dose at 2 wk and 4 wk after initial dose, then every 4 wk thereafter.
- IV (Children ≥6 yr and <75 kg): 10 mg/kg initially; repeat dose at 2 wk and 4 wk after initial dose, then every 4 wk thereafter.
- SC (Children ≥2 yr and ≥50 kg): 125 mg once weekly.
- SC (Children ≥2 yr and 25–<50 kg): 87.5 mg once weekly.
- SC (Children ≥2 yr and 10–<25 kg): 50 mg once weekly.
Psoriatic Arthritis
- IV (Adults >100 kg): 1000 mg initially; repeat dose at 2 wk and 4 wk after initial dose, then every 4 wk thereafter.
- IV (Adults 60–100 kg): 750 mg initially; repeat dose at 2 wk and 4 wk after initial dose, then every 4 wk thereafter.
- IV (Adults <60 kg): 500 mg initially; repeat dose at 2 wk and 4 wk after initial dose, then every 4 wk thereafter.
- SC (Adults ): 125 mg once weekly.
- SC (Children ≥2 yr and ≥50 kg): 125 mg once weekly.
- SC (Children ≥2 yr and 25–<50 kg): 87.5 mg once weekly.
- SC (Children ≥2 yr and 10–<25 kg): 50 mg once weekly.
Prophylaxis of Acute Graft Versus Host Disease
- IV (Adults and Children ≥6 yr): 10 mg/kg (max dose = 1000 mg) on the day before transplantation; repeat dose on Days 5, 14, and 28 after transplantation.
- IV (Children 2–<6 yr): 15 mg/kg on the day before transplantation, then 12 mg/kg on Days 5, 14, and 28 after transplantation.
