REMS
Hemady
Absorption: Well absorbed after oral administration. Sodium phosphate salt is rapidly absorbed after IM administration. Absorption from local sites (intra-articular, intralesional) is slow but complete.
Distribution: Widely distributed to tissues.
Half-Life: Low birth weight infants with bronchopulmonary dysplasia: 9.3 hr; Children 3 mo16 yr: 4.3 hr; Adults: 34.5 hr (plasma), 3654 hr (tissue); adrenal suppression lasts 2.75 days.
(anti-inflammatory activity)
ROUTE | ONSET | PEAK | DURATION |
PO | unknown | 12 hr | 72 hr |
IM, IV (phosphate) | rapid | unknown | 72 hr |
Contraindicated in:
Use Cautiously in:
Adverse reactions/side effects are much more common with high-dose/long-term therapy
CV: hypertension, edema
Derm: ↓wound healing, acne, ecchymoses, hirsutism, petechiae
EENT: ↑intraocular pressure, blurred vision, cataracts
Endo: adrenal suppression, hyperglycemia
F and E: hypokalemia, metabolic alkalosis
GI: anorexia, nausea, PEPTIC ULCERATION, vomiting
GU: amenorrhea
Hemat: THROMBOEMBOLISM, thrombophlebitis
MS: muscle wasting, osteoporosis, avascular necrosis of joints, muscle pain
Neuro: depression, euphoria, ↑intracranial pressure (children only), psychoses, hallucinations, headache, insomnia, personality changes, restlessness
Misc: cushingoid appearance (moon face, buffalo hump), INFECTION, KAPOSI'S SARCOMA
Drug-drug:
Lab Test Considerations:
Rate: Administer infusions over 1530 min.
Y-Site Incompatibility:
IV Administration:
NDC Code