soo-ma-TRIP-tan
Therapeutic Classification: vascular headache suppressants
Pharmacologic Classification: five ht1 agonists
Absorption: Well absorbed (97%) after SUBQ administration. Absorption after oral administration is incomplete and significant amounts undergo substantial hepatic metabolism, resulting in poor bioavailability (14%). Well absorbed after intranasal administration.
Distribution: Well distributed to tissues.
Half-Life: 2 hr.
(relief of migraine)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | within 30 min | 2–4 hr | up to 24 hr |
| SUBQ | 30 min | up to 2 hr | up to 24 hr |
| Nasal | within 60 min | 2 hr | unknown |
Contraindicated in:
Use Cautiously in:
CV: angina, chest pressure, chest tightness, coronary vasospasm, ECG changes, MI, transient hypertension
Derm: tingling, warm sensation, burning sensation, cool sensation, flushing
EENT: alterations in vision, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Local: injection site reaction
MS: jaw discomfort, muscle cramps, myalgia, neck pain, neck stiffness
Neuro: dizziness, vertigo, anxiety, drowsiness, fatigue, feeling of heaviness, feeling of tightness, headache, malaise, numbness, tight feeling in head, weakness
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)
Drug-drug:
Drug-Natural Products:
Hepatic Impairment
Nasal Powder
Remove clear device cap from the reusable delivery device, then remove a disposable nosepiece from foil pouch and click nosepiece into device body. Press fully and promptly release white piercing button on device body to pierce capsule inside nosepiece. White piercing button should only be pressed once and released prior to administration to each nostril. Insert nosepiece into nostril making a tight seal. Rotate device to place mouthpiece into the mouth. Patient blows forcefully through mouthpiece to deliver the sumatriptan powder into nasal cavity. Vibration (e.g., a rattling noise) may occur, and indicates that patient is blowing forcefully, as directed. Once medication in the first nosepiece has been administered, remove and discard nosepiece.NDC Code