section name header

Pronunciation ⬇

se-TI-ra-zeen

Classifications ⬆ ⬇

Therapeutic Classification: allergy, cold and cough remedies, antihistamines

Pharmacologic Classification: piperazines (peripherally selective)

Indications ⬆ ⬇

REMS

PO

IV

Action ⬆ ⬇

  • Antagonizes the effects of histamine at H1-receptor sites; does not bind to or inactivate histamine.
  • Anticholinergic effects are minimal, and sedation is dose related.
Therapeutic effects:
  • Decreased symptoms of histamine excess (sneezing, rhinorrhea, ocular tearing and redness, pruritus).

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration. IV administration results in complete bioavailability.

Distribution: Unknown.

Protein Binding: 93%.

Metabolism/Excretion: Excreted primarily unchanged by the kidneys.

Half-Life: 7.4–9 hr (↓ in children to 6.2 hr, ↑ in renal impairment up to 19–21 hr).

Time/Action Profile ⬆ ⬇

(antihistaminic effects)

ROUTEONSETPEAKDURATION
PO30 min4–8 hr24 hr
IVunknownunknownunknown



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: acute generalized exanthematous pustulosis

EENT: pharyngitis

GI: dry mouth

Neuro: dizziness, drowsiness (significant with oral doses >10 mg/day), fatigue

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

IV Administration:

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Quzyttir, ZyrTEC

Canadian Brand Names ⬆ ⬇

Reactine

Code ⬆

NDC Code