proe-METH-a-zeen
Therapeutic Classification: antiemetics, antihistamines, sedative/hypnotics
Pharmacologic Classification: phenothiazines
BEERS REMS, High Alert
Absorption: Well absorbed after oral (88%) and IM administration; rectal administration may be less reliable. IV administration results in complete bioavailability.
Distribution: Widely distributed to tissues.
Half-Life: 9–16 hr.
(noted as antihistaminic effects; sedative effects last 2–8 hr)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO, IM | 20 min | unknown | 4–12 hr |
| Rectal | 20 min | unknown | 4–12 hr |
| IV | 3–5 min | unknown | 4–12 hr |
Contraindicated in:
Use Cautiously in:
CV: bradycardia, hypertension, hypotension, tachycardia
Derm: photosensitivity, rash, severe tissue necrosis upon infiltration at IV site
EENT: blurred vision, diplopia, tinnitus
GI: constipation, dry mouth, hepatitis
Hemat: blood dyscrasias
Neuro: confusion, disorientation, sedation, dizziness, extrapyramidal reactions, fatigue, insomnia, nervousness, NEUROLEPTIC MALIGNANT SYNDROME
Drug-drug:
Antihistamine
Antivertigo (Motion Sickness)
Sedation
If administered IV, assess for burning and pain at IV site; may cause severe tissue injury. Avoid IV administration, if possible. If pain occurs, discontinue administration immediately.
Lab Test Considerations:
IV Administration:
NDC Code