section name header

Pronunciation ⬇

TRAZ-oh-done

Classifications ⬆ ⬇

Therapeutic Classification: antidepressants

Indications ⬆ ⬇

REMS

Unlabeled Use:

Action ⬆ ⬇

  • Alters the effects of serotonin in the CNS.
Therapeutic effects:
  • Antidepressant action, which may develop only over several wk.

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed to tissues.

Protein Binding: 89–95%.

Metabolism/Excretion: Extensively metabolized by the liver via the CYP3A4 isoenzyme; minimal excretion of unchanged drug by the kidneys.

Half-Life: 5–9 hr.

Time/Action Profile ⬆ ⬇

(antidepressant effect)

ROUTEONSETPEAKDURATION
PO1–2 wk2–4 wkwk



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension, arrhythmias, chest pain, hypertension, palpitations, QT interval prolongation, tachycardia

Derm: rash

EENT: blurred vision, tinnitus

GI: dry mouth, constipation, diarrhea, excess salivation, flatulence, nausea, vomiting

GU: erectile dysfunction, hematuria, priapism, urinary frequency

Hemat: anemia, leukopenia

MS: myalgia

Neuro: drowsiness, confusion, dizziness, dysgeusia, fatigue, hallucinations, headache, insomnia, nightmares, slurred speech, SUICIDAL THOUGHTS, syncope, tremor, weakness

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Route/Dosage ⬆ ⬇

Depression

Insomnia

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Desyrel

Pill Image

trazodone-hcl_195-9199.jpg

Code ⬆

NDC Code