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Pronunciation ⬇

MEK-li-zeen

Classifications ⬆ ⬇

Therapeutic Classification: antiemetics, antihistamines

Indications ⬆ ⬇

BEERS REMS

Action ⬆ ⬇

  • Has central anticholinergic, CNS depressant, and antihistaminic properties.
  • Decreases excitability of the middle ear labyrinth and depresses conduction in middle ear vestibular-cerebellar pathways.
Therapeutic effects:
  • Decreased motion sickness.
  • Decreased vertigo from vestibular pathology.

Pharmacokinetics ⬆ ⬇

Absorption: Absorbed after oral administration.

Distribution: Unknown.

Metabolism/Excretion: Primarily metabolized by liver via the CYP2D6 isoenzyme; the CYP2D6 isoenzyme exhibits genetic polymorphism (∼7% of population may be poor metabolizers and may have significantly ↑ meclizine concentrations and an ↑ risk of adverse effects).

Half-Life: 6 hr.

Time/Action Profile ⬆ ⬇

(antihistaminic effects)

ROUTEONSETPEAKDURATION
PO1 hrunknown8–24 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

EENT: blurred vision

GI: dry mouth

Neuro: drowsiness, fatigue

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Antivert, Bonine

Code ⬆

NDC Code