Therapeutic Classification: antipyretics, antirheumatics, nonopioid analgesics
Pharmacologic Classification: nonsteroidal anti inflammatory drugs nsaids
BEERS REMS
Absorption: Oral formulation is well absorbed (80%) from the GI tract; IV administration results in complete bioavailability.
Distribution: Does not enter breast milk in significant amounts.
Protein Binding: 99%.
Half-Life: Neonates: 2643 hr; Children: 12 hr; Adults: 24 hr.
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO (antipyretic) | 0.52.5 hr | 24 hr | 68 hr |
PO (analgesic) | 30 min | 12 hr | 46 hr |
PO (anti-inflammatory) | ≤7 days | 12 wk | unknown |
IV (analgesic) | unknown | unknown | 6 hr |
IV (antipyretic) | within 2 hr | 1012 hr‡ | 46 hr |
‡With repeated dosing.
Contraindicated in:
Use Cautiously in:
CV: arrhythmias, edema, HF, hypertension, MI
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), EXFOLIATIVE DERMATITIS, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS
EENT: amblyopia, blurred vision, tinnitus
F and E: hyperkalemia
GI: constipation, dyspepsia, nausea, vomiting, abdominal discomfort, GI BLEEDING, HEPATITIS, necrotizing enterocolitis (ibuprofen lysine)
GU: cystitis, hematuria, renal failure
Hemat: anemia, blood dyscrasias, prolonged bleeding time
Local: injection site reaction
Neuro: headache, dizziness, drowsiness, intraventricular hemorrhage (ibuprofen lysine), psychic disturbances, STROKE
Drug-drug:
Drug-Natural Products:
Analgesia/Anti-inflammatory/Antipyretic
Pediatric OTC Dosing
Patent Ductus Arteriosus Closure
Lab Test Considerations:
IV Administration:
Ibuprofen
Ibuprofen Lysine
ibuprofen: Advil, Advil Infants, Advil Junior Strength, Advil Migraine, Children's Advil, Childrens Motrin, Motrin IB, Motrin Infants Drops, Motrin Junior Strength, PediaCare IB Ibuprofen,
ibuprofen (injection): Caldolor, NeoProfen (ibuprofen lysine)
NDC Code