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Pronunciation

eye-byoo-PROE-fen

Classifications

Therapeutic Classification: antipyretics, antirheumatics, nonopioid analgesics

Pharmacologic Classification: nonsteroidal anti inflammatory drugs nsaids

Indications

BEERS REMS


Action

  • Inhibits prostaglandin synthesis.
Therapeutic effects:
  • Decreased pain and inflammation.
  • Reduction of fever.
  • Closure of PDA.

Pharmacokinetics

Absorption: Oral formulation is well absorbed (80%) from the GI tract; IV administration results in complete bioavailability.

Distribution: Does not enter breast milk in significant amounts.

Protein Binding: 99%.

Metabolism/Excretion: Mostly metabolized by the liver; small amounts (1%) excreted unchanged by the kidneys.

Half-Life: Neonates: 26–43 hr; Children: 1–2 hr; Adults: 2–4 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
PO (antipyretic)0.5–2.5 hr2–4 hr6–8 hr
PO (analgesic)30 min1–2 hr4–6 hr
PO (anti-inflammatory)7 days1–2 wkunknown
IV (analgesic)unknownunknown6 hr
IV (antipyretic)within 2 hr10–12 hr4–6 hr



With repeated dosing.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: arrhythmias, edema, HF, hypertension, MI

Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), EXFOLIATIVE DERMATITIS, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS

EENT: amblyopia, blurred vision, tinnitus

F and E: hyperkalemia

GI: constipation, dyspepsia, nausea, vomiting, abdominal discomfort, GI BLEEDING, HEPATITIS, necrotizing enterocolitis (ibuprofen lysine)

GU: cystitis, hematuria, renal failure

Hemat: anemia, blood dyscrasias, prolonged bleeding time

Local: injection site reaction

Neuro: headache, dizziness, drowsiness, intraventricular hemorrhage (ibuprofen lysine), psychic disturbances, STROKE

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Analgesia/Anti-inflammatory/Antipyretic

Pediatric OTC Dosing

Patent Ductus Arteriosus Closure

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

IV Administration:

Ibuprofen

Ibuprofen Lysine

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

ibuprofen: Advil, Advil Infants, Advil Junior Strength, Advil Migraine, Children's Advil, Children’s Motrin, Motrin IB, Motrin Infants Drops, Motrin Junior Strength, PediaCare IB Ibuprofen,

ibuprofen (injection): Caldolor, NeoProfen (ibuprofen lysine)

Canadian Brand Names

ibuprofen: Children's Europrofen, Motrin

Pill Image

ibuprofen_195-9222.jpg

Code

NDC Code