omega-3-acid ethyl esters

oh-ME-ga three AS-id ETH-il ES-ters

Therapeutic Classification: lipid-lowering agents

Pharmacologic Classification: fatty acids

REMS

Hypertriglyceridemia (triglycerides ≥500 mg/dL).

Inhibits synthesis of triglycerides.

Therapeutic effects:

Reduction of triglycerides.

Absorption: Well absorbed.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Incorporated into phospholipids.

Half-Life: Unknown.

(lowering of triglycerides)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	2 mo	unknown

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

Allergy/hypersensitivity to fish;
OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding;
Pedi: Safety and effectiveness not established in children.

Derm: rash

GI: ↑liver enzymes, altered taste, eructation

Drug-drug:

May ↑ risk of bleeding with aspirin or warfarin.

PO (Adults ): 4 g once daily or 2 g twice daily.

(Generic available)

Gelatin capsules (oil-filled): 1 g

Obtain a diet history, especially with regard to fat consumption.

Lab Test Considerations:

Monitor serum triglyceride levels prior to and periodically during therapy.
- Monitor serum ALT periodically during therapy. May cause ↑ serum ALT without concurrent ↑ in AST levels.
- Monitor serum LDL cholesterol levels periodically during therapy. May cause ↑ in serum LDL levels.

Do not confuse Lovaza with lorazepam.
An appropriate lipid-lowering diet should be followed before therapy and should continue during therapy.
PO: May be taken as a single 4-g dose or as 2 g twice daily. May be administered with meals. DNC: Swallow capsules whole; do not break, dissolve, or chew.

Instruct patient to take medication as directed, not to skip doses or double up on missed doses. Take missed doses as soon as remembered, but if a day is missed, do not double doses the next day. Medication helps control but does not cure elevated serum triglyceride levels.
Advise patient that this medication should be used in conjunction with diet restrictions (fat, cholesterol, carbohydrates, alcohol), exercise, weight loss in overweight patients, and control of medical problems (such as diabetes mellitus and hypothyroidism) that may contribute to hypertriglyceridemia.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected, or if breastfeeding.
Emphasize the importance of follow-up exams to determine effectiveness.

Lowering of serum triglyceride levels. Patients who do not have an adequate response after 2 mo of treatment should be withdrawn from therapy.

Lovaza

NDC Code

0093- Teva Pharmaceuticals USA, Inc.
- 0093-5401- Omega-3-Acid Ethyl Esters
  - 0093-5401-89- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (0093-5401-89)

0173- GlaxoSmithKline LLC
- 0173-0884- LOVAZA
  - 0173-0884-08- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (0173-0884-08)

0254- Par Pharmaceutical Inc.
- 0254-3010- Omega-3-acid ethyl esters
  - 0254-3010-08- 120 CAPSULE in 1 BOTTLE (0254-3010-08)

16714- NorthStar Rx LLC
- 16714-660- Omega-3-Acid Ethyl Esters
  - 16714-660-01- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (16714-660-01)

31722- Camber Pharmaceuticals Inc.
- 31722-936- Omega-3-acid ethyl esters
  - 31722-936-05- 500 CAPSULE, LIQUID FILLED in 1 BOTTLE (31722-936-05)

31722- Camber Pharmaceuticals Inc.
- 31722-936- Omega-3-acid ethyl esters
  - 31722-936-12- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (31722-936-12)

42291- AvKARE, Inc.
- 42291-657- Omega-3-acid ethyl esters
  - 42291-657-12- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (42291-657-12)

42708- QPharma Inc
- 42708-067- Omega-3-Acid Ethyl Esters
  - 42708-067-28- 28 CAPSULE, LIQUID FILLED in 1 BOTTLE (42708-067-28)

49884- Par Pharmaceutical, Inc.
- 49884-019- Omega-3-Acid Ethyl Esters
  - 49884-019-02- 60 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC (49884-019-02)

49884- Par Pharmaceutical, Inc.
- 49884-019- Omega-3-Acid Ethyl Esters
  - 49884-019-08- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC (49884-019-08)

50090- A-S Medication Solutions
- 50090-3742- Omega-3-acid ethyl esters
  - 50090-3742-0- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (50090-3742-0)

50090- A-S Medication Solutions
- 50090-3956- Omega-3-Acid Ethyl Esters
  - 50090-3956-0- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC (50090-3956-0)

60429- Golden State Medical Supply, Inc.
- 60429-912- Omega-3-Acid Ethyl Esters
  - 60429-912-12- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC (60429-912-12)

60505- Apotex Corp.
- 60505-3170- Omega-3-acid ethyl esters
  - 60505-3170-3- 30 CAPSULE, LIQUID FILLED in 1 BOTTLE (60505-3170-3)

60505- Apotex Corp.
- 60505-3170- Omega-3-acid ethyl esters
  - 60505-3170-6- 60 CAPSULE, LIQUID FILLED in 1 BOTTLE (60505-3170-6)

60505- Apotex Corp.
- 60505-3170- Omega-3-acid ethyl esters
  - 60505-3170-7- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (60505-3170-7)

60505- Apotex Corp.
- 60505-4462- Omega-3-acid ethyl esters
  - 60505-4462-7- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (60505-4462-7)

60687- American Health Packaging
- 60687-127- Omega-3-acid ethyl esters
  - 60687-127-65- 50 BLISTER PACK in 1 BOX, UNIT-DOSE (60687-127-65) > 1 CAPSULE, LIQUID FILLED in 1 BLISTER PACK (60687-127-11)

62559- ANI Pharmaceuticals, Inc.
- 62559-410- Omega-3-Acid Ethyl Esters
  - 62559-410-12- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (62559-410-12)

63629- Bryant Ranch Prepack
- 63629-6805- Omega-3-Acid Ethyl Esters
  - 63629-6805-1- 30 CAPSULE, LIQUID FILLED in 1 BOTTLE (63629-6805-1)

63629- Bryant Ranch Prepack
- 63629-6805- Omega-3-Acid Ethyl Esters
  - 63629-6805-2- 90 CAPSULE, LIQUID FILLED in 1 BOTTLE (63629-6805-2)

64380- Strides Pharma Science Limited
- 64380-761- omega-3-acid ethyl esters
  - 64380-761-11- 120 CAPSULE in 1 BOTTLE (64380-761-11)

65162- Amneal Pharmaceuticals LLC
- 65162-034- Omega-3-Acid Ethyl Esters
  - 65162-034-06- 60 CAPSULE, LIQUID FILLED in 1 BOTTLE (65162-034-06)

65162- Amneal Pharmaceuticals LLC
- 65162-034- Omega-3-Acid Ethyl Esters
  - 65162-034-16- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (65162-034-16)

65162- Amneal Pharmaceuticals LLC
- 65162-034- Omega-3-Acid Ethyl Esters
  - 65162-034-32- 360 CAPSULE, LIQUID FILLED in 1 BOTTLE (65162-034-32)

66993- Prasco Laboratories
- 66993-726- Omega-3-acid ethyl esters
  - 66993-726-32- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (66993-726-32)

69452- Bionpharma Inc.
- 69452-175- Omega-3-Acid Ethyl Ester
  - 69452-175-17- 60 CAPSULE, LIQUID FILLED in 1 BOTTLE (69452-175-17)

69452- Bionpharma Inc.
- 69452-175- Omega-3-Acid Ethyl Ester
  - 69452-175-22- 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (69452-175-22)

69837- International Brand Management Inc
- 69837-170- OMEGA-3-ACID ETHYL ESTERS
  - 69837-170-03- 30 CAPSULE in 1 BOTTLE (69837-170-03) > 1 g in 1 CAPSULE (69837-170-02)

69837- International Brand Management Inc
- 69837-170- OMEGA-3-ACID ETHYL ESTERS
  - 69837-170-05- 120 CAPSULE in 1 BOTTLE (69837-170-05) > 1 g in 1 CAPSULE (69837-170-31)

69837- International Brand Management Inc
- 69837-170- OMEGA-3-ACID ETHYL ESTERS
  - 69837-170-30- 30 CAPSULE in 1 BOTTLE (69837-170-30) > 1 g in 1 CAPSULE (69837-170-31)

70518- REMEDYREPACK INC.
- 70518-1636- Omega-3-acid ethyl esters
  - 70518-1636-0- 60 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC (70518-1636-0)

70518- REMEDYREPACK INC.
- 70518-1636- Omega-3-acid ethyl esters
  - 70518-1636-1- 180 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC (70518-1636-1)

70518- REMEDYREPACK INC.
- 70518-1636- Omega-3-acid ethyl esters
  - 70518-1636-2- 360 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC (70518-1636-2)

70518- REMEDYREPACK INC.
- 70518-2319- Omega-3-Acid Ethyl Esters
  - 70518-2319-0- 180 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC (70518-2319-0)

72189- Direct_Rx
- 72189-024- OMEGA-3-ACID ETHYL ESTERS
  - 72189-024-30- 30 CAPSULE, LIQUID FILLED in 1 BOTTLE (72189-024-30)

72189- Direct_Rx
- 72189-024- OMEGA-3-ACID ETHYL ESTERS
  - 72189-024-60- 60 CAPSULE, LIQUID FILLED in 1 BOTTLE (72189-024-60)

72189- Direct_Rx
- 72189-024- OMEGA-3-ACID ETHYL ESTERS
  - 72189-024-90- 90 CAPSULE, LIQUID FILLED in 1 BOTTLE (72189-024-90)

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Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Route/Dosage ⬆ ⬇

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Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

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