lor-AZ-e-pam
Therapeutic Classification: analgesic adjuncts, antianxiety agents, sedative/hypnotics
Pharmacologic Classification: benzodiazepines
IV:
BEERS REMS, High Alert
Absorption: Well absorbed following oral administration. Rapidly and completely absorbed following IM administration. Sublingual absorption is more rapid than oral and is similar to IM. IV administration results in complete bioavailability.
Distribution: Widely distributed. Crosses the blood-brain barrier. Crosses the placenta; enters breast milk.
Half-Life: Full-term neonates: 18–73 hr; Older children: 6–17 hr; Adults: 10–16 hr.
(sedation)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | 15–60 min | 1–6 hr | 8–12 hr |
| PO-XR | unknown | unknown | unknown |
| IM | 30–60 min | 1–2 hr‡ | 8–12 hr |
| IV | 15–30 min | 15–20 min | 8–12 hr |
‡Amnestic response.
Contraindicated in:
Use Cautiously in:
CV: bradycardia, hypotension,
rapid IV use only
APNEA, CARDIAC ARRESTDerm: rash
EENT: blurred vision
GI: constipation, diarrhea, nausea, vomiting
Neuro: dizziness, drowsiness, lethargy, ataxia, confusion, forgetfulness, hangover, headache, mental depression, rhythmic myoclonic jerking in pre-term infants, paradoxical excitation, slurred speech
Resp: respiratory depression
Misc: physical dependence, psychological dependence, tolerance
Drug-drug:
Drug-Natural Products:
Status Epilepticus
Preanesthetic
Anxiety
Lab Test Considerations:
Toxicity and Overdose:
IV Administration:
NDC Code
