cefaclor

Therapeutic Classification: anti-infectives

Pharmacologic Classification: second generation cephalosporins

REMS

Treatment of the following infections caused by susceptible organisms:
- Respiratory tract infections,
- Skin and skin structure infections,
- Urinary tract infections,
- Otitis media.

Binds to bacterial cell wall membrane, causing cell death.

Therapeutic effects:

Bactericidal action against susceptible bacteria.

Spectrum:

Similar to that of first-generation cephalosporins but has increased activity against several other gram-negative pathogens including:
- Haemophilus influenzae,
- Escherichia coli,
- Klebsiella pneumoniae,
- Proteus mirabilis.
Not active against methicillin-resistant staphylococci or enterococci.

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed. Penetration into CSF is poor. Crosses the placenta and enters breast milk in low concentrations.

Metabolism/Excretion: Excreted primarily unchanged by the kidneys.

Half-Life: 30–60 min (↑ in renal impairment).

ROUTE	ONSET	PEAK	DURATION
PO	rapid	30–60 min	6–12 hr
PO-CD	unknown	unknown	12 hr

Contraindicated in:

Hypersensitivity to cephalosporins;
Serious hypersensitivity to penicillins.

Use Cautiously in:

Renal impairment ;
History of GI disease, especially colitis;
OB: Has been used safely.

Drug-drug:

Probenecid ↓excretion and ↑ blood levels.
Antacids ↓absorption.

PO (Adults ): Immediate-release—250–500 mg q 8 hr; Extended-release—375–500 mg q 12 hr.
PO (Children >1 mo): 6.7–13.4 mg/kg q 8 hr or 10–20 mg/kg q 12 hr (up to 1 g/day).

(Generic available)

Capsules: 250 mg; 500 mg
Extended-release tablets (CD): 375 mg; 500 mg
Oral suspensionstrawberry: 125 mg/5 mL; 187 mg/5 mL; 250 mg/5 mL; 375 mg/5 mL

Assess for infection (vital signs; appearance of wound, sputum, urine, and stool; WBC) at beginning of and during therapy.
Before initiating therapy, obtain a history to determine previous use of and reactions to penicillins or cephalosporins. Persons with a negative history of penicillin sensitivity may still have an allergic response.
Obtain specimens for culture and sensitivity before initiating therapy. First dose may be given before receiving results.
Observe patient for signs and symptoms of anaphylaxis (rash, pruritus, laryngeal edema, wheezing). Discontinue drug and notify health care professional immediately if these symptoms occur. Keep epinephrine, an antihistamine, and resuscitation equipment close by in the event of an anaphylactic reaction.

Lab Test Considerations:

May cause positive results for Coombs' test.
- May cause increased serum AST, ALT, alkaline phosphatase, bilirubin, LDH, BUN, and creatinine.
- May rarely cause neutropenia, agranulocytosis, and eosinophilia.

PO: Administer around the clock. Capsules, or suspension may be administered on full or empty stomach. Administration with food may minimize GI irritation. Extended-release tablets should be taken with food. Shake oral suspension well before administering. Suspension is stable for 14 days after reconstitution if refrigerated.
- Do not administer within 1 hr of taking antacids.
- Do not crush, break, or chew extended-release tablets.

Instruct patient to take medication around the clock at evenly spaced times and to finish medication completely, even if feeling better. Take missed doses as soon as possible unless almost time for next dose; do not double doses. Instruct patient to use calibrated measuring device with suspension. Advise patient that sharing of this medication may be dangerous.
Advise patient to report signs of superinfection (furry overgrowth on the tongue, vaginal itching or discharge, loose or foul-smelling stools) and allergy.
Instruct patient to notify health care professional if fever and diarrhea develop, especially if stool contains blood, pus, or mucus. Advise patient not to treat diarrhea without consulting health care professional.

Resolution of signs and symptoms of infection. Length of time for complete resolution depends on the organism and site of infection.

Risk for infection(Indications)(Side Effects)
Diarrhea(Adverse Reactions)
Deficient knowledge, Relate med(Patient/Family Teaching)

NDC Code

0093- Teva Pharmaceuticals USA, Inc.
- 0093-1087- Cefaclor
  - 0093-1087-01- 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (0093-1087-01)

0143- West-Ward Pharmaceuticals Corp
- 0143-9985- CEFACLOR
  - 0143-9985-01- 100 CAPSULE in 1 BOTTLE (0143-9985-01)

0143- West-Ward Pharmaceuticals Corp
- 0143-9985- CEFACLOR
  - 0143-9985-15- 15 CAPSULE in 1 BOTTLE (0143-9985-15)

0143- West-Ward Pharmaceuticals Corp
- 0143-9986- CEFACLOR
  - 0143-9986-01- 100 CAPSULE in 1 BOTTLE (0143-9986-01)

0143- West-Ward Pharmaceuticals Corp
- 0143-9986- CEFACLOR
  - 0143-9986-15- 15 CAPSULE in 1 BOTTLE (0143-9986-15)

16571- Pack Pharmaceuticals, LLC
- 16571-070- Cefaclor
  - 16571-070-12- 150 mL in 1 BOTTLE (16571-070-12)

16571- Pack Pharmaceuticals, LLC
- 16571-071- Cefaclor
  - 16571-071-12- 150 mL in 1 BOTTLE (16571-071-12)

16571- Pack Pharmaceuticals, LLC
- 16571-072- Cefaclor
  - 16571-072-11- 100 mL in 1 BOTTLE (16571-072-11)

23594- Aytu Therapeutics, LLC
- 23594-125- Cefaclor
  - 23594-125-01- 150 mL in 1 BOTTLE, PLASTIC (23594-125-01)

23594- Aytu Therapeutics, LLC
- 23594-250- Cefaclor
  - 23594-250-01- 150 mL in 1 BOTTLE, PLASTIC (23594-250-01)

23594- Aytu Therapeutics, LLC
- 23594-375- Cefaclor
  - 23594-375-01- 100 mL in 1 BOTTLE, PLASTIC (23594-375-01)

50090- A-S Medication Solutions
- 50090-0518- CEFACLOR
  - 50090-0518-0- 30 CAPSULE in 1 BOTTLE (50090-0518-0)

50090- A-S Medication Solutions
- 50090-0518- CEFACLOR
  - 50090-0518-2- 21 CAPSULE in 1 BOTTLE (50090-0518-2)

59115- Hikma Pharmaceutical
- 59115-071- CEFACLOR
  - 59115-071-01- 100 CAPSULE in 1 BOTTLE (59115-071-01)

59115- Hikma Pharmaceutical
- 59115-071- CEFACLOR
  - 59115-071-15- 15 CAPSULE in 1 BOTTLE (59115-071-15)

59115- Hikma Pharmaceutical
- 59115-072- CEFACLOR
  - 59115-072-01- 100 CAPSULE in 1 BOTTLE (59115-072-01)

59115- Hikma Pharmaceutical
- 59115-072- CEFACLOR
  - 59115-072-15- 15 CAPSULE in 1 BOTTLE (59115-072-15)

61442- Carlsbad Technology, Inc.
- 61442-171- Cefaclor
  - 61442-171-01- 100 CAPSULE in 1 BOTTLE, PLASTIC (61442-171-01)

61442- Carlsbad Technology, Inc.
- 61442-171- Cefaclor
  - 61442-171-05- 500 CAPSULE in 1 BOTTLE, PLASTIC (61442-171-05)

61442- Carlsbad Technology, Inc.
- 61442-171- Cefaclor
  - 61442-171-30- 30 CAPSULE in 1 BOTTLE, PLASTIC (61442-171-30)

61442- Carlsbad Technology, Inc.
- 61442-172- Cefaclor
  - 61442-172-01- 100 CAPSULE in 1 BOTTLE, PLASTIC (61442-172-01)

61442- Carlsbad Technology, Inc.
- 61442-172- Cefaclor
  - 61442-172-05- 500 CAPSULE in 1 BOTTLE, PLASTIC (61442-172-05)

61442- Carlsbad Technology, Inc.
- 61442-172- Cefaclor
  - 61442-172-30- 30 CAPSULE in 1 BOTTLE, PLASTIC (61442-172-30)

61442- Carlsbad Technology, Inc.
- 61442-173- Cefaclor
  - 61442-173-01- 150 mL in 1 BOTTLE, PLASTIC (61442-173-01)

61442- Carlsbad Technology, Inc.
- 61442-173- Cefaclor
  - 61442-173-02- 75 mL in 1 BOTTLE, PLASTIC (61442-173-02)

61442- Carlsbad Technology, Inc.
- 61442-174- Cefaclor
  - 61442-174-01- 100 mL in 1 BOTTLE, PLASTIC (61442-174-01)

61442- Carlsbad Technology, Inc.
- 61442-174- Cefaclor
  - 61442-174-02- 50 mL in 1 BOTTLE, PLASTIC (61442-174-02)

61442- Carlsbad Technology, Inc.
- 61442-175- Cefaclor
  - 61442-175-01- 150 mL in 1 BOTTLE, PLASTIC (61442-175-01)

61442- Carlsbad Technology, Inc.
- 61442-175- Cefaclor
  - 61442-175-02- 75 mL in 1 BOTTLE, PLASTIC (61442-175-02)

61442- Carlsbad Technology, Inc.
- 61442-176- Cefaclor
  - 61442-176-01- 100 mL in 1 BOTTLE, PLASTIC (61442-176-01)

61442- Carlsbad Technology, Inc.
- 61442-176- Cefaclor
  - 61442-176-02- 50 mL in 1 BOTTLE, PLASTIC (61442-176-02)

section name header

Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

Canadian Brand Names ⬆ ⬇

Pot. Nursing Diagnoses ⬆ ⬇

Code ⬆