section name header

Pronunciation

SOE-dee-um bye-KAR-boe-nate

Classifications

Therapeutic Classification: antiulcer agents

Pharmacologic Classification: alkalinizing agents

Indications

REMS


Unlabeled Use:

Action

  • Acts as an alkalinizing agent by releasing bicarbonate ions.
  • Following oral administration, releases bicarbonate, which is capable of neutralizing gastric acid.
Therapeutic effects:
  • Alkalinization.
  • Neutralization of gastric acid.

Pharmacokinetics

Absorption: Following oral administration, excess bicarbonate is absorbed and results in metabolic alkalosis and alkaline urine. IV administration results in complete bioavailability.

Distribution: Widely distributed into extracellular fluid.

Metabolism/Excretion: Sodium and bicarbonate are excreted by the kidneys.

Half-Life: Unknown.

Time/Action Profile

(PO = antacid effect; IV = alkalinization)

ROUTEONSETPEAKDURATION
POimmediate30 min1–3 hr
IVimmediaterapidunknown



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: edema

F and E: metabolic alkalosis, hypernatremia, hypocalcemia, hypokalemia

GI:

PO

flatulence, gastric distention

Local: irritation at IV site

Neuro: cerebral hemorrhage (with rapid injection in infants), tetany

Interactions

Drug-drug:

Route/Dosage

Alkalinization of Urine

Antacid

Systemic Alkalinization/Cardiac Arrest

Renal Tubular Acidosis

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

IV Administration:

Patient/Family Teaching

Evaluation/Desired Outcomes

Code

NDC Code