REMS
Absorption: Following oral administration, excess bicarbonate is absorbed and results in metabolic alkalosis and alkaline urine. IV administration results in complete bioavailability.
Distribution: Widely distributed into extracellular fluid.
Half-Life: Unknown.
(PO = antacid effect; IV = alkalinization)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | immediate | 30 min | 13 hr |
IV | immediate | rapid | unknown |
Contraindicated in:
Use Cautiously in:
CV: edema
F and E: metabolic alkalosis, hypernatremia, hypocalcemia, hypokalemia
GI:
PO
flatulence, gastric distentionLocal: irritation at IV site
Neuro: cerebral hemorrhage (with rapid injection in infants), tetany
Drug-drug:
Alkalinization of Urine
Antacid
Systemic Alkalinization/Cardiac Arrest
Lab Test Considerations:
IV Administration:
NDC Code