section name header

Pronunciation

proe-METH-a-zeen

Classifications

Therapeutic Classification: antiemetics, antihistamines, sedative/hypnotics

Pharmacologic Classification: phenothiazines

Indications

BEERS REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed after oral (88%) and IM administration; rectal administration may be less reliable. IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Metabolized by the liver.

Half-life: 9–16 hr.

Time/Action Profile

(noted as antihistaminic effects; sedative effects last 2–8 hr)

ROUTEONSETPEAKDURATION
PO, IM20 minunknown4–12 hr
Rectal20 minunknown4–12 hr
IV3–5 minunknown4–12 hr

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: bradycardia, hypertension, hypotension, tachycardia.

Derm: photosensitivity, rash, severe tissue necrosis upon infiltration at IV site.

EENT: blurred vision, diplopia, tinnitus.

GI: constipation, dry mouth, hepatitis.

Hemat: blood dyscrasias.

Neuro: confusion, disorientation, sedation, dizziness, extrapyramidal reactions, fatigue, insomnia, nervousness, NEUROLEPTIC MALIGNANT SYNDROME.

Interactions

Drug-Drug:

Route/Dosage

see Calculator

Antihistamine

Antivertigo (Motion Sickness)

Sedation

Nausea/Vomiting

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Phenergan, Promethegan

Code

NDC Code*