Therapeutic Classification: antiemetics, antihistamines, sedative/hypnotics
Pharmacologic Classification: phenothiazines
Absorption: Well absorbed after oral (88%) and IM administration; rectal administration may be less reliable. IV administration results in complete bioavailability.
Distribution: Widely distributed to tissues.
Metabolism/Excretion: Metabolized by the liver.
Half-life: 916 hr.
(noted as antihistaminic effects; sedative effects last 28 hr)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO, IM | 20 min | unknown | 412 hr |
| Rectal | 20 min | unknown | 412 hr |
| IV | 35 min | unknown | 412 hr |
Contraindicated in:
Use Cautiously in:
CV: bradycardia, hypertension, hypotension, tachycardia.
Derm: photosensitivity, rash, severe tissue necrosis upon infiltration at IV site.
EENT: blurred vision, diplopia, tinnitus.
GI: constipation, dry mouth, hepatitis.
Hemat: blood dyscrasias.
Neuro: confusion, disorientation, sedation, dizziness, extrapyramidal reactions, fatigue, insomnia, nervousness, NEUROLEPTIC MALIGNANT SYNDROME.
Drug-Drug:
Antihistamine
2 yr): 0.1 mg/kg/dose (not to exceed 12.5 mg) every 6 hr during the day and 0.5 mg/kg/dose (not to exceed 25 mg) at bedtime.
2 yr): 0.125 mg/kg every 46 hr or 0.5 mg/kg at bedtime.Antivertigo (Motion Sickness)
2 yr): 0.5 mg/kg (not to exceed 25 mg) 3060 min before departure; may be given every 12 hr as needed.Sedation
2 yr): 0.251 mg/kg (not to exceed 25 mg) every 46 hr.(Generic available)
IV Administration:
NDC Code*