section name header

Pronunciation ⬇

sef-A-zoe-lin

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: first generation cephalosporins

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Binds to bacterial cell wall membrane, causing cell death.
Therapeutic effects:
  • Bactericidal action against susceptible bacteria.

Spectrum:

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after IM administration. IV administration results in complete bioavailability.

Distribution: Widely distributed. Penetrates bone and synovial fluid well. Crosses the placenta and enters breast milk in low concentrations. Minimal CSF penetration.

Metabolism/Excretion: Excreted almost entirely unchanged by the kidneys.

Half-Life: Neonates: 3–5 hr; Adults: 90–150 min (↑ in renal impairment).

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTEONSETPEAKDURATION
IMrapid0.5–2 hr6–12 hr
IVrapid5 min6–12 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

GI: diarrhea, nausea, vomiting, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), cramps

Derm: rash, pruritus, STEVENS-JOHNSON SYNDROME, urticaria

Hemat: leukopenia, neutropenia, thrombocytopenia

Local: pain at IM site, phlebitis at IV site

Neuro: SEIZURES(HIGH DOSES)

Misc: allergic reactions including anaphylaxis and , serum sicknesssuperinfection

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Renal Impairment

Renal Impairment

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

IV Administration:

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Ancef

Code ⬆

NDC Code