section name header

Pronunciation ⬇

SEF-di-nir

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: third generation cephalosporins

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Binds to bacterial cell wall membrane, causing cell death.
Therapeutic effects:
  • Bactericidal action against susceptible bacteria.

Spectrum:

Pharmacokinetics ⬆ ⬇

Absorption: 16–25% absorbed after oral administration.

Distribution: Widely distributed.

Protein Binding: 60–70%.

Metabolism/Excretion: Mostly excreted unchanged in urine.

Half-Life: 1.7 hr (↑ in renal impairment).

Time/Action Profile ⬆ ⬇

(blood levels)

ROUTEONSETPEAKDURATION
POrapid2–4 hr12–24 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash, pruritus

GI: diarrhea, vomiting, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), abdominal pain, nausea

GU: vaginal moniliasis, vaginitis

Neuro: headache, SEIZURES

Misc: ANAPHYLAXISALLERGIC REACTIONS INCLUDING

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Renal Impairment

Renal Impairment

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Omnicef

Code ⬆

NDC Code