Therapeutic Classification: antianxiety agents, antidepressants
Pharmacologic Classification: selective serotonin reuptake inhibitors ssris
BEERS REMS
Paxil, Paxil CR, Pexeva
Paxil, Pexeva
Paxil, Paxil CR
Paxil
Paxil CR
Paroxetine mesylate (7.5–mg capsule)
Absorption: Completely absorbed following oral administration. Controlled-release tablets are enteric-coated and control medication release over 4–5 hr.
Distribution: Widely distributed throughout body fluids and tissues, including the CNS; cross the placenta and enter breast milk.
Protein Binding: 95%.
Half-Life: 21 hr.
Contraindicated in:
Use Cautiously in:
CV: chest pain, edema, hypertension, palpitations, postural hypotension, tachycardia, vasodilation
Derm: sweating, photosensitivity, pruritus, rash, STEVENS-JOHNSON SYNDROME (SJS)
EENT: blurred vision, pharyngitis, rhinitis
Endo: SIADH
F and E: hyponatremia
GI: constipation, diarrhea, dry mouth, nausea, abdominal pain, dyspepsia, flatulence, taste disturbances, vomiting
GU: ↓libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction, genital disorders, infertility, urinary disorders, urinary frequency
Hemat: BLEEDING
MS: back pain, bone fracture, myalgia, myopathy
Neuro: anxiety, dizziness, drowsiness, headache, insomnia, weakness, agitation, amnesia, confusion, depression, emotional lability, hangover, impaired concentration, malaise, NEUROLEPTIC MALIGNANT SYNDROME, paresthesia, SUICIDAL THOUGHTS, syncope, tremor
Resp: cough, yawning
Misc: chills, fever, SEROTONIN SYNDROME
Drug-drug:
Drug-Natural Products:
Depression
Obsessive Compulsive Disorder
Panic Disorder
Social Anxiety Disorder
Generalized Anxiety Disorder
Post-Traumatic Stress Disorder
Premenstrual Dysphoric Disorder
Menopausal Vasomotor Symptoms
Hepatic Impairment
Paxil, Paxil CR, or Pexeva:
Severe hepatic impairment: 10 mg/day initially; may slowly ↑ (not to exceed 40 mg/day). Controlled-release tablets: 12.5 mg once daily initially; may slowly ↑ (not to exceed 50 mg/day).Renal Impairment
Paxil, Paxil CR, or Pexeva:
Severe renal impairment: 10 mg/day initially; may slowly ↑ (not to exceed 40 mg/day). Controlled-release tablets: 12.5 mg once daily initially; may slowly ↑ (not to exceed 50 mg/day).Lab Test Considerations:
NDC Code