section name header

Pronunciation

ER-soe-dye-ole

Classifications

Therapeutic Classification: gallstone dissolution agents

Indications

REMS


Unlabeled Use:

Action

  • cholesterol content of bile and bile stones by suppressing cholesterol synthesis and secretion from the liver and inhibits intestinal absorption of cholesterol.
Therapeutic effects:
  • Gallstone dissolution and reduction in gallstone formation.
  • progression of liver disease and improvement in liver function tests.

Pharmacokinetics

Absorption: 90%.

Distribution: Only small quantities are found in the systemic circulation; sites of action include the liver, bile, and gut lumen.

Protein Binding: 70%.

Metabolism/Excretion: Undergoes extensive enterohepatic recycling; excreted in feces via bile.

Half-Life: 100 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
POunknownunknownunknown



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CNS: anxiety, depression, fatigue, headache, sleep disorder

Derm: hair thinning, pruritus, rash

GI: abdominal/biliary pain, constipation, diarrhea, flatulence, jaundice, liver enzymes, nausea, stomatitis, vomiting

Neuro: arthralgias, myalgia

Resp: cough, rhinitis

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Actigall, Urso 250, Urso Forte

Canadian Brand Names

Urso, Urso DS

Pot. Nursing Diagnoses

Code

NDC Code