de-fe-RA-si-rox
REMS
Absorption: Well absorbed (70%) following oral administration, absorption is less in children.
Distribution: Unknown.
Protein Binding: 99%.
Half-Life: 8–16 hr.
Contraindicated in:
Use Cautiously in:
Derm: rash, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS
EENT: ↑intraocular pressure, cataracts, hearing loss, lens opacities, retinal disorders
GI: diarrhea, nausea , vomiting, ↑liver enzymes, abdominal pain, drug-induced hepatitis, GI BLEEDING/ULCERATION, GI PERFORATION, HEPATOTOXICITY
GU: ↑serum creatinine, RENAL FAILURE, renal failure
Hemat: agranulocytosis, neutropenia, thrombocytopenia, worsening anemia
MS: arthralgia
Resp: cough
Misc: fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)
Drug-drug:
Chronic Iron Overload Due to Blood Transfusions
Hepatic Impairment
Renal Impairment
Chronic Iron Overload in Non-Transfusion Dependent Thalassemia Syndromes
Hepatic Impairment
Renal Impairment
Lab Test Considerations:
Jadenu
Swallow tablets whole with water or other liquids on an empty or stomach or with a light meal (contains less than 7% fat content and approximately 250 calories, such as 1 whole wheat English muffin, 1 packet jelly (0.5 ounces), and skim milk (8 fluid ounces) or a turkey sandwich (2 oz. turkey on whole wheat bread with lettuce, tomato, and 1 packet mustard). For patients with difficulty swallowing, tablets may be crushed and mixed with soft foods (yogurt, apple sauce) immediately before administration. Administer Jadenu sprinkle granules on an empty stomach or with a light meal by sprinkling full dose on soft food; administer immediately.NDC Code